Creative Biolabs Enables to Develop Desired PROTAC Molecules

Creative Biolabs has successfully won the leading place in the field of proteolysis-targeting chimera (PROTAC) development, outputting all-round PROTAC molecule discovery solutions and professional technical support.

Shirley, United States – August 13, 2020 /MarketersMedia/ —

With the development of molecular science, scientists have discovered that the proteolysis-targeting chimera, a kind of hetero-bifunctional molecule with two ligands is a promising novel therapeutics. A PROTAC molecule is made up of a ligand to recruit E3 ligase, a linker, and another ligand to bind pathogenic protein, which is a desired property of target therapy. Creative Biolabs has been exploring this field devotedly and has successfully established a pipeline of PROTAC discovery, in vitro evaluation, and in vivo test.

PROTAC molecule discovery is a one-stop solution composed of ligand design for the target protein, ligand screening for E3 ligase, linker design & optimization, structural modification, and custom peptide and compound synthesis, which are supported by doctoral-level scientists with rich experience. It is worth mentioning that the technical team at Creative Biolabs has broken through poorly selective or weak-affinity ligands and generated optimal ligands for MDM2-based PROTAC through various strategies. Mouse Double Minute 2 homologue (MDM2), an essential oncogenic protein conducive to cell growth, survival, invasion, and chemotherapy resistance in cancer, is a negative regulator of the tumor suppressor P53. Cutting down P53 and MDM2 interaction is a potential approach to developing PROTAC-based therapeutics.

In vitro evaluation and in vivo animal test are supplementary services that separately verify the efficacy and safety of PROTAC molecules through a variety of assays.

In addition to the considerate services, necessary composing substances of PROTAC discovery/development are also offered at Creative Biolabs, which are of high quality, intended to facilitate the research of customers, including protac linkers, ligands, E3 ligase and target protein.

* Linkers: Bis-PEG6-acid
* Ligands: BRD9-Binding Moiety 1 Hydrochloride, VH 032 Amine Hydrochloride, Thalidomide Linker 1, dBET1
* E3 ligase & Target Protein: Bromodomain-containing Protein 4, E3 ubiquitin-protein ligase Mdm2
(customize services of ligand design, linker design, and E3 ligase & target protein development available upon requests)

The COVID-19 has been affecting the life of the people throughout the world since its outbreak, hindering economic growth, and posing threats to the health system of the entire world. It seems that most industries have been affected, but the scientists at Creative Biolabs withstand the pressure and keep to their posts, intending to help customers with their emergent projects. According to the head of Creative Biolabs, all of their orders and projects are under normal operation and guaranteed on-time delivery. More details can be accessed at https://www.creative-biolabs.com/protac/.

Company Profile
Creative Biolabs is a leading service provider of PROTAC discovery, offering professional solutions of PROTAC molecule discovery, in vitro evaluation, and in vivo tests, as well as standard linker, ligand, E3 ligase products. Since establishment, Creative Biolabs has gradually organized a group of PROTAC-focused talent team that is made up of Ph.D. level scientists with associated specialties.

Contact Info:
Name: Candy Swift
Email: Send Email
Organization: Creative Biolabs
Website: https://www.creative-biolabs.com/protac/

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Source: MarketersMedia

Release ID: 88972605