Creative Biolabs: Go Beyond Standard PROTAC Discovery

USA – April 20, 2022 /MarketersMEDIA/ —

PROTAC (proteolysis-targeting chimera) has shown considerable potential in targeting proteins that were previously thought to be non-druggable, which functions in synchronization with the ubiquitin-proteasome system (UPS) that is known to be the major pathway for the degradation of intracellular proteins in eukaryotic cells. Once tagged with ubiquitin, the proteins are recognized and will be degraded by the proteasome, and the process is mediated by a series of ubiquitinating enzymes named E1, E2, and E3. 

“We witnessed the discovery, development, regression, and rejuvenation of PROTAC,” said a scientist, “as we have been exploring this field for over a decade.”

Acknowledging that the PROTAC-based drug possesses huge potential, Creative Biolabs, after years of in-depth study, has successfully established a platform offering custom PROTAC discovery solution, covering the entire workflow of a PROTAC molecule generation: ligand design for the protein of interest (POI), ligand screening for E3 ligase, PROTAC linker optimization, structure modification, and peptide and compound synthesis.

“Clients can place an order for our one-stop discovery service package,” added the scientist, “and the only thing to do is to designate the target protein.”

A PROTAC candidate should go through assessments to validate its efficacy and, more importantly, safety. Creative Biolabs has classified its services according to the way a molecule is evaluated.

Comprehensive in vitro evaluation assays ensure that a PROTAC is up to the standard in terms of solubility and chemical stability, meanwhile possessing outstanding cell permeability efficacy. Other factors like cell cytotoxicity, target ubiquitination, and target degradation are covered as well. Animal models of diverse species help test the PROTAC in vivo toxicity, absorption, distribution, metabolism, and excretion, to exhaustively validate it as a candidate with full potential.

Superior to conventional CROs specializing in PROTAC discovery, Creative Biolabs has excellent foresight, and has in-stock prepared products available for quick shipment, fueling customers’ projects with shortened timelines.

• Linkers
• Ligands
• E3 ligase and target proteins

Learn more about PROTAC solutions at https://www.creative-biolabs.com/protac/.

About

Creative Biolab is a CRO possessing expertise in PROTAC-based drug discovery. After years of exploration, it has developed into a pioneer holding exclusive technology platforms such as CLIPTAC, Homo-PROTAC, HaloPROTAC, ATTEC, and Trivalent PROTACS.

Contact Info:
Name: Candy Swift
Email: Send Email
Organization: Creative Biolabs
Website: https://www.creative-biolabs.com/protac/

Release ID: 89073530

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