Creative Biogene Launches Comprehensive Exosome Marker Lentiviral Particles to Support The Study of Exosome Release, Uptake and Biodistribution
Creative Biogene announced the release of its comprehensive exosome marker lentiviral particles to support the study of exosome release, uptake and biodistribution mechanisms.
New York, USA – January 18, 2021 /MarketersMedia/ —
Creative Biogene, the world’s leading biotechnology provider focuses on developing high-quality products and services to support the research in the field of basic life sciences research, biomedical development, industrial synthetic application and preclinical drug discovery. Recently, Creative Biogene announced the release of its comprehensive exosome marker lentiviral particles to support the study of exosome release, uptake and biodistribution mechanisms.
As a leader in lentiviral technology, Creative Biogene has developed a complete human, mouse and rat gene library, which can be cloned into lentiviral vectors or ready-to-use lentiviruses, which can be used to manipulate target genes in a wide range of expression host cell. The comprehensive lentiviral solution suite offered by Creative Biogene includes ready-to-use particles for cell culture and animals, plasmid clones expressing ORF, miRNA, shRNA and sgRNA, including but not limited to CAR-T lentiviral particles, cell immortalization lentiviral particles, iPS lentiviral particles.
Due to its unique advantages and significant improvements in the recombinant lentiviral system, lentiviral vectors are now widely used in basic biology and translation studies for stable transgene overexpression, continuous gene silencing, immunization, transgenic animals, and stem cells modification. In addition, since most retroviruses cannot effectively infect undivided cells, lentiviruses can infect cells regardless of their proliferation status, which makes them particularly attractive for human gene therapy. Neurons, hepatocytes, hematopoietic stem cells, monocytes and macrophages are some examples of potential targets for lentiviral vector-based gene therapy.
Exosomes are secreted nanovesicles with a diameter between 30 and 150 nm and are produced in the endosomal compartment of most eukaryotic cells. They are present in all body fluids under normal and pathophysiological conditions. They play an important role in mediating cell-to-cell communication by acting as carriers of different biomolecules, including proteins, RNA and lipids from one cell to another. Exosomes have common characteristics, such as certain four-span membrane proteins (CD9, CD63 and CD81), heat shock proteins, proteins related to biogenesis, membrane transport and fusion proteins, nucleic acids (mRNA, miRNA and long non-coding RNA and DNA) and lipids.
These unique characteristics of exosomes provide opportunities for innovation in diagnosis and treatment. The transport of vesicles between cells plays an important role in many aspects of human health and disease, including development, immunity, tissue homeostasis, cancer and neurodegenerative diseases. Therefore, there is an increasing interest in the clinical application and therapeutic use of exosomes as biomarkers.
“The lentiviral particles provided by Creative Biogene can effectively express the exosome biomarkers CD9, CD63 and CD81 with different reporter genes (tdTomato, mCherry-Flag, Flag-Gluc). These constructs can help you track the packaging, secretion, targeting and transport mechanisms of exosomes.” said Marcia Brady, the marketing director of Creative Biogene, she also added, “if you have specific needs for any research, we will provide a customized plan for you then.”
About Creative Biogene
Creative Biogene, as a top-of-its-kind company that holds a leading position and is committed to accelerating the development of human science through biotechnology, offering innovative technologies, products, unique tools and services for research discoveries and product development. With more than 10 years of experience and in-house experts, Creative Biogene has become a well-recognized industry leader to support researchers worldwide.
Contact Info:
Name: Marcia Brady
Email: Send Email
Organization: Creative Biogene
Address: NY 11967, USA
Phone: 1 631 386 8241
Website: https://www.creative-biogene.com/
Source: MarketersMedia
Release ID: 88993923
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