Due Diligence Report: Phase 2 Success; Phase 3 the Real Test

NEW YORK, NY / ACCESSWIRE / October 1, 2015 / Vascular Bellerophon Therapeutics LLC. (NASDAQ: BLPH) a clinical-stage biotherapeutics company, announced that INOpulse(R), an inhaled treatment of nitric oxide entering phase 3 testing for the treatment of pulmonary arterial hypertension, improved vasodilation in patients with pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD). In the trial, 6 subjects (3 male and 3 female between the ages of 65-79) with pulmonary hypertension associated with COPD on long-term oxygen therapy were given an acute dose of INOpulse inhaled nitric oxide. Following treatment, the subjects underwent functional respiratory imaging to determine the geometry of their lungs, airway and pulmonary vascular structures.

Jonathan Peacock, Chairman and Chief Executive Officer of Bellerophon Therapeutics, stated, “We continue to be encouraged by the progress we are making in the development of INOpulse as a potential treatment for pulmonary hypertension. This late-breaker session at the ERS Congress builds on earlier studies indicating that INOpulse has the potential to reduce pulmonary hypertension in COPD patients. In the next several months, we plan to test the effect of reducing pulmonary hypertension on exercise capacity for these patients.”

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About Bellerophon Therapeutics LLC

Bellerophon Therapeutics LLC, a clinical-stage therapeutics company, focuses on the development of various products for the treatment of cardiopulmonary and cardiac diseases. Its product candidates include INOpulse, a pulsatile nitric oxide delivery device, which has completed Phase II clinical trials for the treatment of pulmonary arterial hypertension, as well as in Phase II clinical trials to treat pulmonary hypertension associated with chronic obstructive pulmonary diseases; and bioabsorbable cardiac matrix, a medical device for the prevention of congestive heart failure. The company was formerly known as Ikaria Development LLC and changed its name to Bellerophon Therapeutics LLC in January 2014. Bellerophon Therapeutics LLC was founded in 2009 and is headquartered in Hampton, New Jersey.

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