Creative Biolabs’ Extensive Capability of Therapeutic Glycoprotein Development
Creative Biolabs is an expert in the fields of antibody and protein development. Regarding the powerful therapeutic approach, glycoprotein, Creative Biolabs has organized a group of scientists who have professional knowledge and rich experience to help clients develop the optimal glycoprotein.
Shirley, United States – October 7, 2020 /MarketersMedia/ —
Crucial molecules involved in the immune response are glycoproteins and many therapeutic proteins like vaccines, antibodies and enzymes that require glycans to have full biological activity. Generated by means of glycosylation that modifies the yield, bioactivity, solubility, stability against proteolysis, immunogenicity, and clearance rate from circulation, the therapeutic glycoprotein is made up of glycans which covalently attach to the amino acid side-chains. Creative Biolabs has been exploring in the development and engineering of this fastest-growing field for years and provides customize solutions to help produce glycoproteins that satisfy various research targets.
To help produce glycans with determined/adapted properties, various glycan modification and glycan labeling technologies are adopted in the high-end technology platforms at Creative Biolabs, enabling a variety of glycan and modification operations.
Glycan fluorescence labeling can be applied not only in the fields of protein and nucleic acids, at Creative Biolabs, solutions including boronic acid-based fluorescent detection of carbohydrates, in situ visualization fluorescent labeling of carbohydrates, and fluorescent labeling of glycolipids are also provided. The comprehensive solutions can no doubt help optimize the fluorescence-based assays to obtain real-time, high-resolute, and accurate results.
Other chemical reactions are also performed as labeling methods to create derivatives with designated properties, such as biotinylation, sulfation, PEGylation, phosphorylation, and acetylation.
Biotinylation is popularly applied in the research of interactions because of its fast speed, specificity without perturbing the natural function. The scientists utilize several strategies to perform biotinylation according to clients’ requests, including N-hydroxysuccinimide (NHS), enzymatic biotinylation with E. coli biotin ligase (BirA), and proximity-dependent biotin identification (BioID).
In addition to the glycan labeling technologies, several efficient glycoengineered expression platforms and different production platforms are also the highlights, which include glycoengineered mammalian cell expression system, glycoengineered pichia pastoris expression system, and glycoengineered plant-based expression system to provide a completely new class of therapeutic glycoprotein with customized functions. More details about the platforms can be accessed at https://www.creative-biolabs.com/glycoprotein/.
Company Overview
Creative Biolabs is a leading service provider in the field of glycoprotein, which provides not only custom synthesis, glycoengineering service, glycoprotein analysis, but also has the capability to design and develop anti-glycoprotein antibody and vaccine. Based on the cutting-edge technology platforms, Creative Biolabs has successfully accomplished dozens of projects in the past decade. The service portfolio continues expanding, aiming to help every customer in relevant fields.
Contact Info:
Name: Candy Swift
Email: Send Email
Organization: Creative Biolabs
Website: https://www.creative-biolabs.com/glycoprotein/
Source: MarketersMedia
Release ID: 88979960
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