Drug-Free, Anti-Inflammatory Formula Significantly Reduces Cold Symptoms.

A drug-free, anti-inflammatory formula made from naturally derived ingredients significantly reduced common cold symptoms, according to researchers at Applied Biological Laboratories. Two key components, lysozyme and lactoferrin, are naturally produced anti-inflammatory agents and an important part of the innate immune system.

New York, United States – August 15, 2023 —

According to researchers at Applied Biological Laboratories, a newly developed, naturally derived, drug-free formula containing a mucosal immune complex can significantly reduce common cold symptoms such as runny nose, sneezing, sore throat, and cough in people, and it uses an entirely novel approach to cold care.

Lysozyme and lactoferrin, two key components of the mucosal immune complex, are important bioactive molecules naturally found in plants and animals, as well as in our tears and mucus. They manage inflammation and strengthen the immune system, according to numerous peer reviewed scientific studies by researchers world-wide. Now, researchers at Applied Biological Laboratories report that a throat spray formula containing the mucosal immune complex can reduce numerous common cold symptoms in people. This, according to Applied Biological Laboratories, is an entirely new approach to managing cold and flu symptoms since most other treatments block pain receptors without addressing inflammation. Other treatments, they add, may even contain ingredients that damage delicate respiratory tissue. The research will be presented at the American Chemical Society Fall Conference on Aug 15, 2023, in San Francisco California, and is also being submitted for peer review.

According to previously published peer- reviewed studies, the mechanism of action involves a combination of anti-inflammatory activities as well as viral inactivation, and immune cell activation. 

The research, led by Nazlie Sadeghi-Latefi, PhD, Co-Founder and Chief Scientific Officer of Applied Biological Laboratories emphasizes the importance of supporting respiratory (or mucosal) barrier immunity and managing inflammation to prevent and treat cold and flu symptoms.

Dr. Latefi asserts, the respiratory barrier is similar to the gut and skin barrier and is the body’s first line of defense against invading pathogens, such as those causing the common cold and influenza. It is active in the critical first hours or days after infection. As mentioned, lysozyme and lactoferrin are naturally produced in tears and mucus along the nose and throat. The mucosal lining also contains resident immune cells such as macrophages and dendritic cells, which are activated by lysozyme and lactoferrin, and which, if necessary, help recruit antibodies via the adaptive immune system. Once someone is infected, mucosal immunity and barrier strength play a crucial role in controlling inflammation and tissue damage immediately, in turn limiting illness severity and duration.

Lysozyme and lactoferrin help modulate inflammation and relieve cold symptoms.

Lysozyme and lactoferrin have very broad anti-inflammatory effects and are involved in numerous biochemical pathways. Researchers at Applied Biological Laboratories believe lysozyme and lactoferrin can be effective on their own or combined with other natural anti-inflammatory molecules such as COX inhibitors in a mucosal immune complex to make them even more effective.

One of the key inflammatory signals in respiratory inflammation involves prostaglandin generation via COX enzymes. These mediators are responsible for many cold and flu symptoms such as runny nose, sore throat, congestion, and cough, and are initially set off by bradykinin, an inflammatory molecule similar to histamine. Researchers at Applied Biological Laboratories tested numerous doses of natural, plant-based acetyl salicylic acid (aspirin), a well-known COX inhibitor. According to their previously published peer reviewed study using in vitro human respiratory tissue, lower doses were more effective than higher doses, and when combined with lysozyme and lactoferrin, the anti-inflammatory effects were even greater and reached statistical significance.

Clinical trial confirms the synergistic benefits of drug-free natural bioactive molecules lysozyme and lactoferrin in treating cold & flu symptoms.

To confirm the published laboratory studies and test the formulations clinically, a randomized, double-blinded placebo-controlled study was conducted. Participants were randomly assigned to receive either placebo or a throat spray formulation containing lysozyme, lactoferrin, menthol and various COX inhibitors such as aloe vera extract or plant-based aspirin. Symptoms were measured using visual analog scales (VAS) and a modified Jackson score. Upper respiratory inflammation as measured by the sore throat pain intensity scale was the primary endpoint. Secondary endpoints included reduction of other common cold symptoms such as nasal discharge and congestion, sneezing, sore/scratchy throat, cough, headache, malaise, and fever as assessed by the modified Jackson scale. The trial enrolled 179 participants who self-administered the throat spray.

ALL the treatment groups had a significant reduction in almost all upper respiratory symptoms tested. This data strongly supports the efficacy of formulas containing the mucosal immune complex in alleviating common cold symptoms, including nasal congestion, discharge, sneezing, sore/scratchy throat, cough, headache, malaise, and fever/chills. Researchers at Applied Biological Laboratories are submitting their study for peer review and detailed results will be made available once the full study is published.

According to the researchers, Biovanta’s mucosal immune complex also strengthens the respiratory lining by maintaining its thickness and by preventing microscopic tears from inflammatory cytokines and they add, no other cold and flu product works this way.

Popular cold & flu remedies may do more harm than good.

In their previously published peer reviewed study, investigators compared the effects of Biovanta’s mucosal immune complex containing lysozyme and lactoferrin to the most popular over-the-counter cough and cold medications using in vitro human respiratory tissue models. According to the study, most popular OTC medications damage the respiratory barrier, creating microscopic tears, killing cells, and increasing inflammation even more, which could possibly prolong infection or lead to unnecessary side-effects. You probably don’t feel this happening, say the researchers, because most OTC cough and cold medications are actually pain relievers that inactivate pain signals without healing the respiratory tissue.

Implications and Impact

The potential implications of these results are significant given the vast number of people affected by the common cold and flu every season. Every year, an average household shops for over-the-counter medications 26 times a year, spending an average of $338. To date, few studies have evaluated the impact of these medications on mucosal barrier integrity, which can affect symptom severity, illness duration, and susceptible to secondary infections.

 References:

1.   Common colds: Overview. (2020). Institute for Quality and Efficiency in Health Care (IQWiG).

2.   Ell, K. (2017). 7 ways to meet the costs of cold and flu season. USA Today.

3. Molecular Biology of the Cell. 4th edition, https://www.ncbi.nlm.nih.gov/books/NBK26846

About Us: Biovanta, developed by Applied Biological Laboratories, brings confidence in combating cold and flu symptoms, utilizing natural bioactive molecules, lysozyme and lactoferrin. Its scientifically-validated formula supports the mucosal barrier, reduces inflammation, and stimulates innate immune responses without damaging mucosal integrity. Distinguished from traditional OTC remedies, Biovanta is available in over 28,000 pharmacies nationwide, making it a reliable and accessible solution for effective symptom relief. Biovanta Immunity now available for purchase on Biovanta.com and on Amazon.

Contact Info:
Name: Karissa Rischall
Email: Send Email
Organization: Applied Biological Laboratories
Address: 760 Parkside Ave, Brooklyn, NY 11226
Website: https://www.Biovanta.com

Release ID: 89103597

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