Monthly Archives: March 2023

Tony Amaradio – Talks About the Connection between Faith and Leadership Traits

According to Amaradio, spirituality provides entrepreneurs with additional leverage as it guides them to operate in a manner that promotes building organizations where business success does not come at the expense of morality, ethics, and compassion.

Aliso Viejo, California, United States – March 1, 2023 /MarketersMEDIA/

It is a common belief that the corporate world is not a place where spirituality belongs. But, US history has shown many examples of successful business founders who stayed true to their faith. Among them is Tony Amaradio, a financial expert whose religious devoutness has informed his decisions in both business and personal matters, establishing him as an outstanding professional, an inspirational philanthropist, and a published author whose book, Faithful with Much: Breaking Down the Barriers to Generous Giving, is now available on Amazon in Kindle, Hardcover, and Paperback formats. According to Amaradio, spirituality provides entrepreneurs with additional leverage as it guides them to operate in a manner that promotes building organizations where business success does not come at the expense of morality, ethics, and compassion. 

Maltbie Babcock, a distinguished 19th-century clergyman and writer, famously said, that business is religion, and religion is business. The man who does not make a business of his religion has a religious life of no force, and the man who does not make a religion of his business has a business life of no character. One thing that unites all the faiths of the world is that they invariably stress the importance of honesty, integrity, family values, hard work, respect, and generosity, Tony Amaradio notes. Some of the largest companies were founded by people who applied these principles both to their private and business lives, the list including Sam Walton (retail giant Walmart), Dave Thomas (burger chain Wendy’s), and James Cash Penney (department stores operator J.C. Penny). In addition to drawing on their faith to build thriving enterprises, these leaders were celebrated for their philanthropy and created foundations which have supported countless worthy causes over the decades. In more recent times, devout high-profile executives such as Indra Nooyi (PepsiCo leader from 2001 to 2018), Donnie Smith (head of Tyson Foods, 2009-2016), Pierre Omidyar (founder of eBay), and James Tisch (CEO of Loews Corporation since 1999) have spoken about faith as an integral part of how they run their businesses. They consistently credit religion and spirituality with teaching them to be fair, truthful, generous, socially responsible, ethical, and tolerant – qualities that have shaped their professional decisions and earned them a place in the ranks of the most successful corporate leaders of modern times.

One person uniquely qualified to discuss the positive impact of faith on leadership and work practices is Reverend Scotty McLennan, who is also a lawyer, book author, public speaker, and lecturer in political economy at the Stanford Graduate School of Business. He remarked in an interview that business people spend the majority of their waking hours at work, and many of them want to find this meaningful. Many also want to conduct their business affairs ethically, and the majority of business people around the world learn their ethics through their religions or through philosophical understanding of morality that they inherit from their families, education and surrounding culture. McLennan believes that leaders who integrate spirituality and ethical commitments into their professional lives build more successful business ventures and deliver greater satisfaction to customers and company stakeholders.

Financial expert and dedicated philanthropist Tony Amaradio is the founder and leader of Select Portfolio Management Inc and Select Money Management Inc, where he employs an innovative integrated strategy to maximize results for clients. Following the receipt of a BBA from the University of Michigan and an MBA from the University of Detroit, he commenced his career in the financial services industry, developing his talent over time to garner a stellar reputation and become recognized as a visionary and an inspirational leader. He and his wife Carin are passionate supporters of charitable causes and are often invited to speak at events hosted by non-profit organizations, many of which rely on his expertise to optimize their capacities and thus improve their effectiveness.

Anthony Amaradio – Visionary & Strategic Philanthropist: http://anthonyamaradionews.com

Tony Amaradio – The Best Thing You’ve Ever Done! on Vimeo: https://vimeo.com/313895972

Anthony Amaradio – Facebook: https://www.facebook.com/Anthony-Amaradio-580623782054204/

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Name: Anthony Amaradio
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Organization: AnthonyAmaradioNews.com
Website: http://www.anthonyamaradionews.com

Video URL: https://www.youtube.com/watch?v=Nz0jAilnkPg

Release ID: 89091217

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Advanced Air Conditioning and Heat Launches New Website

A heating and air conditioning team that works out of Vero Beach, FL, has just announced the launch of their new website. The Advanced Air and Conditioning site is designed to ensure customers can get the information they need, including how to get in touch.

United States – March 1, 2023


Advanced Air Conditioning and Heat is an HVAC repair team that works out of Vero Beach, FL, serving its customers and the surrounding areas with experienced and professional services, and they have just launched a new website. This site includes a host of pages that can help clients find out more about the services they need, as well as about the team that can provide them.

On the front page of the new website, customers can learn about many of the perks of choosing Advanced Air Conditioning and Heat as the team to provide the HVAC repair that they need, as well as the process that the team uses to provide those services. Customers can also learn more about the specific kinds of help that the team provides by visiting their service pages. The site has pages for different services like air conditioner parts replacements and repair, heater parts replacements and repair, as well as other air conditioning services and specialized offerings like indoor air purification. 

Also featured on the site is a pins page that highlights the locations that the team has worked in before, as well as an Areas Served section, showing many of the locales in that Advanced Air Conditioning and Heat is able to provide their services. This includes locations like Boca Raton, Fuellsmere, Fort Pierce, Melbourne, Palm Bay, River Park, Wellington, West Palm Beach and more. There is also a reviews page that collects reviews from sites like Google Reviews and then displays them on the website. The site also includes a blog that will address many of the topics and questions related to HVAC that clients might be wondering about.

Advanced Air Conditioning and Heat is a locally based HVAC team that aims to provide professional, honest, and reliable service to those customers in their service areas, no matter what. They offer 24-hour service in the Vero Beach area and can take care of many jobs on the same day that clients make the initial call, including repairs and maintenance for all kinds of makes and models.

To learn more about Advanced Air Conditioning and Heat and the services that they provide, you can visit their website directly at https://www.advancedairirc.com/

Please address and send all press inquiries to Phil Brantley, who can be reached by mail at 8246 93rd Ave, Vero Beach, FL 32967 or on the phone at (772) 388-1695. Email inquiries can be sent directly to wmdigitalprgroup@protonmail.com.

Contact Info:
Name: Phil Brantley
Email: Send Email
Organization: Advanced Air Conditioning and Heat
Address: 8246 93rd Ave, Vero Beach, FL 32967
Phone: (772) 388-1695
Website: https://www.advancedairirc.com/

Release ID: 89091187

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Local HVAC Company Launches New Website

Enterprise Air Conditioning and Refrigeration is an HVAC company based in Mercedes, TX, that has launched a brand new website. This site aims to help its customers with descriptive service pages, an informative blog, a reviews page, and more.

United States – March 1, 2023


A local provider of heating and AC services for customers in Mercedes, TX and the surrounding areas, Enterprise Air Conditioning and Refrigeration has launched a new website that aims to help its customers learn everything they need to know about the help they can provide. With a range of HVAC services at the ready, they work with both residential and commercial clients.

The new Enterprise Air Conditioning and Refrigeration website outlines many of the benefits of working with them to fulfil the client’s HVAC needs, with their process and the values they work by visible on the main page of the site. Customers who want to learn more about what, exactly, they can do can also visit the service pages. Here, they can see information on air conditioner parts replacements and repair, heater parts replacements and repair, as well as other air conditioning services and specialized offerings like their commercial HVAC services. These service pages go into much more detail about the specific kinds of help that the team at Enterprise Air Conditioning & Refrigeration can offer.

The site offers more information besides these service descriptions, too. For instance, their reviews page pulls all of the customer reviews from sites like Google Reviews, so visitors can get the real and genuine opinions of those happy customers Enterprise Air Conditioning & Refrigeration has worked with. There is also a pins page that shows the various locations the team has worked in before, as well as pages on the different areas they serve, from Alamo to Edinburgh, Mcallen to Mission, Palmview to San Juan, and more.

Enterprise Air Conditioning and Refrigeration also host a blog with informative and helpful posts addressing all manner of HVAC questions. This way, people who have basic questions may be able to have them answered without having to even get in touch and get a little advice on what to do in certain scenarios.

Enterprise Air Conditioning & Refrigeration is a full-service heating and air conditioning company in Mercedes, TX. Their team has the experience necessary to provide assistance with any air conditioning or heating issues that clients may be experiencing in addition to a variety of refrigeration services.

To learn more about Enterprise Air Conditioning & Refrigeration and the services that they provide, you can visit their website directly at https://www.enterac.com/.

Please address and send all press inquiries to Maryann Quiroz, who can be reached by mail at 311 Vogel Dr Mercedes, TX 78570 or on the phone at (956) 514-1052. Email inquiries can be sent directly to wmdigitalprgroup@protonmail.com.

Contact Info:
Name: Maryann Quiroz
Email: Send Email
Organization: Enterprise Air Conditioning & Refrigeration
Address: 311 Vogel Dr Mercedes, TX 78570
Phone: (956) 514-1052
Website: https://www.enterac.com/

Release ID: 89091185

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Pennsylvania-based Commercial Roofer Publishes New Website

Five Star Roof Solutions is a commercial roofing team that is based in Pennsylvania, PA, that has launched a new website designed to help customers learn more about their services. This includes service pages, reviews, and an informative and helpful blog.

United States – March 1, 2023

Locally owned and operated, the Pennsylvania-based commercial roofer, Five Star Roof Solutions has launched a new website that welcomes customers and clients who want to learn more about the services that the team can provide. The website contains service pages that offer information on the range of quality services that the team offers, as well as information on areas served, reviews from past clients, and a blog with helpful and informative posts on all manner of subjects related to roofing.

The service pages are a central part of the new Five Star Roof Solutions website, giving the reader plenty of detail on the services available to commercial clients within their service area. As a certified Conklin roofing dealer, this team is able to offer an extensive range of services, including foam roofing, flat roofing, metal roofing, and roof coatings. Conklin products are some of the most widely sought-after on the market, and clients can learn more about them through the website as well.

The website also contains a host of other information that aims to make their services all the more accessible and convenient to the client. This includes a pins page as well as pages for each of the areas that they serve, which includes locations all throughout PA, such as Bloomsberg, Carlisle, Dover, Hamilton, Johnstown, Lancaster, Patton, Reading, Whitehall, Windsor, and more. The site also maintains a helpful blog addressing all manner of roofing questions, such as looking at the benefits and attributes of types of roofing, how to address certain roofing issues, and the like.

Five Star Roof Solutions is an experienced Amish roofing team that is based locally and, as such, knows the importance of building a good reputation amongst the local commercial client base. From quality metal roof restoration to single-ply roof membrane installations, they have the expertise needed on the team to ensure that the client’s desires are met to the most satisfactory degree and bring a focus on superior craftsmanship, aided by top-notch customer service.

To learn more about Five Star Roof Solutions, Inc, a Pennsylvania commercial roofing company, its services, and the many features that its website offers, you can visit it directly at https://www.fivestarroofsolutions.com/

Please address and send any press inquiries directly to Abner Fisher, who can be reached by mail at 127 Woodward Gap Road Woodward, PA 16882, or by phone at (814) 810-6982. All email inquiries can be sent directly to wmdigitalprgroup@protonmail.com.

Contact Info:
Name: Abner Fisher,
Email: Send Email
Organization: Five Star Roof Solutions
Address: 127 Woodward Gap Road Woodward, PA 16882
Phone: (814) 810-6982
Website: https://www.fivestarroofsolutions.com/

Release ID: 89091162

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Pilates Plus LA, Top Lagree Fitness Studios, Celebrates Over 15 Years In the Los Angeles Fitness Community

The leading Lagree fitness studio in Los Angeles, Pilates Plus LA, is celebrating 15 years as part of the local fitness community. They continue to offer a commitment to exceptional fitness experiences while serving their clients for the years ahead.

Los Angeles, CA, California, United States – March 1, 2023

Pilates Plus LA, also known as PPLA, the leading Lagree fitness studios in Los Angeles, has been a pillar of the fitness community in Los Angeles for over 15 years. PPLA has been providing fitness enthusiasts with 45-minute classes that combine strength, endurance, cardio, balance, and flexibility, resulting in a comprehensive full-body workout that delivers results.

Since its founding in 2006 with its Encino studio, PPLA has become known for its commitment to excellence in both Lagree fitness instruction and customer service. The studios feature state-of-the-art Megaformers and experienced instructors who provide personalized attention to each and every client. With locations in Burbank, Encino, Malibu, Studio City, and Woodland Hills, PPLA has become a go-to destination for fitness enthusiasts of all levels.

CEO and Founder Kristi Vacanti said, “We are thrilled to be celebrating over 15 years of support from our amazing clients and to continue to be the top Lagree fitness studios in Los Angeles. We are grateful for our incredible team of coaches and the Los Angeles fitness community. Our commitment to delivering an exceptional Lagree fitness experience remains unwavering, and we look forward to serving our clients for many more years to come.”

PPLA offers a signature class called MegaBurn 45, which delivers a low-impact, high-intensity total-body workout, blending strength training, and cardio to enhance endurance, flexibility, and overall strength. With dimmed lighting and upbeat music, this 45-minute class caters to all fitness levels. The Lagree signature moves are customizable, allowing individuals to amplify or modify them to achieve individual goals.

PPLA has been providing fitness enthusiasts with 45-minute classes that combine strength, endurance, cardio, balance, and flexibility, resulting in a comprehensive full-body workout that delivers results. For more information on Pilates Plus LA and to book a class, visit www.pilatesplusla.co.

Please address and send all press inquiries to Pilates Plus LA by mailing to their address at 13205 Ventura Blvd, Studio City, CA 91604 or by calling on phone at (818) 646-0955. Email inquiries can be sent directly to studiocity@pilatesplusla.co.

Contact Info:
Name: Pilates Plus LA
Email: Send Email
Organization: Pilates Plus LA
Address: 13205 Ventura Blvd, Studio City, CA 91604
Phone: (818) 646-0955
Website: http://www.pilatesplusla.co

Release ID: 89091161

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Chino California Based Plumbing Company Launches New Website

JIG Plumbing, a California-based plumbing company, launches a brand-new website to draw in new audiences in the Chino area.

Chino, California, United States – March 1, 2023

JIG Plumbing has recently launched a brand-new website to appeal to audiences within the Chino, CA area. The fresh redesign includes new features, such as a comprehensive reviews page and map pins, but also offers new content in the form of service pages and informative blog posts. The new website has been built for the purpose of growing the company’s presence in the California area but also serves as the foundation of its digital presence.

JIG Plumbing has completely reworked its service pages, organizing them into simplified categories to make finding the right service a breeze. Each service page has thorough descriptions of what the company is capable of doing, and they also give examples of when those services are needed.

The website also includes a reviews page which pulls ratings and descriptions straight from Google and Yelp. These are paired with testimonials from satisfied clients, giving readers more peace of mind knowing that they’re working with a reputable plumbing company. The pins page is also a new addition. It displays a local map of the areas that JIG Plumbing operates in and places pins on areas in which they have previously worked on. This feature works like a showcase of their work, providing potential clients with photographic proof of what they’re capable of.

Founded in 2011, JIG Plumbing has over 20 years of experience in the plumbing industry. However, the company has only recently begun to nurture a digital presence with its social media pages and business listings on various directories. This new website will serve as their online storefront with descriptive service pages, real customer testimonials, and an informative blog to educate their audience. It will provide a solid foundation for organic search engine optimization, but also become the go-to resource for plumbing advice in the Chino, CA area.

To learn more about JIG Plumbing’s services, clients can refer to the contact details below to get in touch. Alternatively, they can visit the JIG Plumbing website for further details about their services and the company.

Contact Info:
Name: Jason Ganczak
Email: Send Email
Organization: JIG Plumbing
Address: 14415 Mountain Ave Chino, CA 91710
Phone: (844) 899-9054
Website: https://www.jigplumbinginc.com

Release ID: 89091160

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Creative Proteomics Enhances Your Project with Cell Surface Proteomics Service

Based on its biotin affinity purification technology, Creative Proteomics has upgraded the cell surface protein purification and enrichment protocols to enable high-quality extraction of cell surface proteins for subsequent profiling.

New York, United States – March 1, 2023 /MarketersMEDIA/

Creative Proteomics is an integrated CRO company committed to providing a full range of services in order to support various proteomic research projects, ranging from the identification of single proteins to large-scale proteomic studies. Based on its biotin affinity purification technology, the company has upgraded the cell surface protein purification and enrichment protocols to enable high-quality extraction of cell surface proteins for subsequent profiling.

Cell surface proteins perform vital functions for cellular function management and communication between the cell and cellular environment by transporting metabolites, ions, other solutes, and more. Moreover, cell surface proteins vary between different cell types, and specific cell types can be altered between normal and diseased states.

Cell surface proteins are involved in various important applications, i.e., distinguishing between cell phenotypes and disease states, developing prognostic and therapeutic targets, etc., because key biomarkers and potential drug targets of diseases are generally presented on the cell surface. Currently, approximately 70% of biopharmaceuticals developed target cell surface proteins, making the study of surface proteins particularly important and providing a potential avenue for new disease treatments.

Compared with intracellular proteins, the extraction of surface proteins from hydrophobic membranes and aqueous media usually results in low efficiency, not to mention the low abundance of surface proteins that hinder surface protein analysis. Therefore, Creative Proteomics has endeavored to investigate and address these issues by developing a platform for cell surface protein analysis.

“Equipped with the Q Exactive HF MS and Orbitrap Fusion Lumos MS platforms, we can provide professional and comprehensive cell surface proteomics services, including the entire workflow of cell surface protein extraction utilizing mass spectrometry to protein identification and protein quantification,” said a senior scientist of Creative Proteomics.

“With the help of powerful bioinformatics and technologies, our technicians with rich analytical experience in the field of bioinformatics are excited to use various bioinformatics analysis tools to deeply analyze and mine data, realizing comprehensive potential biomarker screening,” he further added.

State-of-the-art equipment, highly trained and experienced staff, as well as verified methodologies are utilized to enable the consistent and high-quality delivery of data with cost efficiency. Based on its highly experienced and knowledgeable scientific team in protein identification, Creative Proteomics can provide fast turnarounds, concise written reports, and comprehensive customized services to help resolve customers’ analytical and technical challenges.

About Creative Proteomics

Creative Proteomics, a seasoned provider of proteomics, metabolomics, and bioinformatics services, is well equipped with advanced technologies in order to meet the increasing needs of scientists in proteome and metabolism research.

Contact Info:
Name: Dora West
Email: Send Email
Organization: Creative Proteomics
Website: https://www.creative-proteomics.com/

Release ID: 89091145

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Pronalyse Announces the Launch of Epitope Mapping Service Utilizing HDX-MS Technology

Based on years of experience supporting protein characterization research, Creative Proteomics Pronalyse has launched the epitope mapping service utilizing HDX-MS, allowing linear and conformational epitope characterization with high resolution and the highest success rate.

New York, United States – March 1, 2023 /MarketersMEDIA/

Pronalyse is a subdivision of Creative Proteomics, an integrated CRO company with rich experience in providing drug development services. Based on years of experience supporting protein characterization research, Creative Proteomics Pronalyse has launched the epitope mapping service utilizing HDX-MS, allowing linear and conformational epitope characterization with high resolution and the highest success rate.

Epitopes are the basis of protein antigenicity, and the study of protein antigenic epitopes is of great significance for the design of new vaccines, diagnostic reagents, peptides, and therapeutic antibodies with appropriate immunogenicity and neutralizing activity. The Hydrogen-deuterium exchange mass spectrometry (HDX-MS), an emerging technique at the forefront of protein research, can provide information regarding amino acid sequences located on the surface of the protein’s spatial structure (including dynamic changes), elucidating possible active sites and protein-protein interaction sites.

Hydrogen-deuterium exchange (HDX) coupled with mass spectrometry (MS) can be used to analyze the conformation of protein biopharmaceuticals as well as to detect their higher-order structural dynamics and epitope mappings. HDX-MS is a powerful and informative technique and is increasingly used for binding site and chemometric analyses. Meanwhile, it enables the monitoring of changes for therapeutic proteins with higher-order structures and examining protein dynamics and associations with other proteins and biomolecules.

As an analytical tool for protein structure and molecular dynamics, HDX-MS is mainly used to help scientists gain insight into the structural changes of proteins. This technology has a wide range of applications in antigen-antibody mutual recognition research, new vaccine development, drug development, etc. Antigenic epitopes are a very important aspect in the development of new protein formulations, and the discovery of promising epitopes often leads to significant commercial outcomes, crucial for patent protection.

“The epitope mapping service by HDX-MS is superior to other methods because the vast majority of epitopes (estimated at approximately 90%) are considered conformational epitopes composed of non-contiguous sequence elements that cannot be effectively identified in low-resolution analysis. We provide state-of-the-art instruments and services in compliance with the HDX-MS technology to rapidly characterize binding sites. To date, we have successfully identified epitopes of dozens of antigens with hundreds of antibodies,” stated Pronalyse’s project manager.

About Creative Proteomics

Creative Proteomics is an innovative contract research organization that focuses on using advanced equipment platforms and optimized detection technology to help researchers around the world reduce time and costs. The company has a proprietary laboratory information management system to strengthen laboratory quality monitoring and management, ensuring the efficiency and security of customer data.

Contact Info:
Name: Dora West
Email: Send Email
Organization: Creative Proteomics
Website: https://www.creative-proteomics.com/

Release ID: 89091146

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Creative Proteomics Cytokine Boosts Cancer Research with Cancer Cytokines Assay

Recently, the product manager of Creative Proteomics was pleased to announce the launch of its Cancer Cytokines Assay, assisting in the detection of multiple cytokine levels within a single sample.

New York, NY, United States – March 1, 2023 /MarketersMEDIA/

Cytokine, a subdivision of Creative Proteomics, specializes in providing cytokine research and analytical services for researchers in the pharmaceutical and biotechnology industries, as well as academic institutes and government agencies. Recently, the product manager of the company was pleased to announce the launch of its Cancer Cytokines Assay, assisting in the detection of multiple cytokine levels within a single sample.

The cocktail of cytokines produced in the cancer microenvironment has important roles in cancer pathogenesis. Cytokines released during infection, inflammation, and immune responses can inhibit cancer initiation and progression. Additionally, cancer cells can be responsive to host-derived cytokines, i.e., inducing cancer cell proliferation, attenuating apoptosis, and promoting cellular invasion and metastasis, etc.

The release of cytokines is stimulated by a variety of cellular stress responses, including carcinogen-induced injury, infection, and inflammation. In these cases, the function of cytokines is to stimulate host responses thus controlling cellular stress and minimizing cellular damage. Although effective damage control can promote tissue repair, unhealed damage can lead to the continuous production of cytokines, which can aggravate tissue destruction. Thus, host responses to cellular stress can influence various stages of cancer development and progression.

Tumor cell-derived vascular endothelial growth factors (VEGFs) act on endothelial cells to promote angiogenesis and tumor growth, invasion, and metastasis. At tumor sites, monocytes differentiate into tumor-associated macrophages capable of inducing growth factors, proteases, angiogenic mediators, and cytokines such as TNFα, IL-1 and IL-6, and chemokines. Chemokines such as CXCL10 (IP-10) and CXCL9 may inhibit cancer development. In addition, adhesion molecules, such as ICAM-1, ICAM-3, VCAM-1, and selectins, are expressed by various tumor cells and are often key factors in metastatic malignancy.

“Creative Proteomics has a professional cancer cytokine detection platform—the Luminex cytokine detection platform. This Luminex platform adapted the fluorescently encoded microspheres with specific antibodies targeting different molecules. These microspheres can be combined freely to a certain extent so that up to 100 analytes can be tested simultaneously in a single experiment,” stated a senior scientist from Creative Proteomics.

“We also offer different analytic strategies, such as real-time quantitative polymerase chain reaction, ELISA and flow cytometry, to meet your unique research needs. We’ll design the most appropriate technology combination according to your project and help researchers obtain higher-quality scientific research data,” he further added.

About Creative Proteomics

Creative Proteomics is an innovative contract research organization that focuses on using advanced equipment platforms and optimized detection technologies to help researchers around the world reduce time and costs. The company has a proprietary laboratory information management system to strengthen laboratory quality monitoring and management, ensuring the efficiency and security of customer data.

Contact Info:
Name: Melissa George
Email: Send Email
Organization: Creative Proteomics
Website: https://www.creative-proteomics.com/

Release ID: 89091144

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CD Genomics Longseq Division Unveils Human Leukocyte Antigen (HLA) Typing Service

The Product Manager of the Long-Read Sequencing Division announced the launch of the Human Leukocyte Antigen (HLA) Typing service to support high-resolution HLA typing in a rapid and cost-efficient manner.

New York, United States – March 1, 2023 /MarketersMEDIA/

CD Genomics is a leading global life sciences company committed to providing the research community with high-quality long-read sequencing services, from Oxford Nanopore to PacBio SMRT sequencing. The Product Manager of the Long-Read Sequencing Division announced the launch of the Human Leukocyte Antigen (HLA) Typing service to support high-resolution HLA typing in a rapid and cost-efficient manner.

HLA is a group of glycoproteins that play an important role in the body’s immune system, encoded by the short arm of human chromosome 6. HLA genes are highly polymorphic, with several to hundreds of different alleles at each locus.

HLA regions are associated with the greatest number of human diseases in the human genome, and HLA typing is particularly important for assessing immune compatibility between organ donor and recipient pairs. There are more than 100 kinds of diseases related to HLA, involving autoimmune diseases, immunodeficiency diseases, allergic diseases, infectious diseases, metabolic diseases, and so on. At the same time, HLA plays a vital role in organ and bone marrow transplantation and is also associated with serious adverse reactions to different medications. Therefore, HLA typing is essential to the research of immune-related diseases, the screening of vaccine and drug target populations, the study of ethnic evolution, tissue, organ transplantations, etc.

The HLA gene products can be expressed on different cell surfaces and play critical roles in antigen presentation and immune signaling. It is closely related to disease defense, organ transplant rejections, and adverse drug reactions. Therefore, HLA typing is widely applied in susceptible gene detection for immune-related diseases, hematopoietic stem cell transplantation (HSCT), and drug allergy testing.

There are mainly three classes of HLA, including HLA class I (e.g., HLA-A, HLA-B, and HLA-C), HLA class II gene (e.g., HLA-DP, HLA-DQ, and HLA-DR), and HLA class III genes. Among them, the HLA class I and II play critical roles in immune responses, with HLA class I genes encoding antigens primarily for CD8+ T cells and HLA class II genes encoding antigens primarily for CD4+ T cells.

CD genomics utilizes third-generation sequencing technologies, including Oxford Nanopore Technologies (ONT) and Pacific Bio (PacBio), which support high-resolution HLA typing in a rapid and cost-efficient manner, contributing to a better understanding of HLA function, its causal relationship to disease, etc.

“Our analytical services include basic and advanced bioinformatics, depending on the client’s project requirements, timeframes, and budgets. Basic bioinformatics services provide de novo HLA gene assembly, HLA annotation, and HLA analysis, while advanced bioinformatics services include shared HLA type screening, significance analysis based on statistical tests, and more,” stated CD Genomics’ senior scientist.

About CD Genomics

CD Genomics focuses on innovative applications of long-read sequencing technologies, genomics analysis methods, and internet concepts in the pharmaceutical and biotechnology industries, as well as scientific and agricultural research. Equipped with advanced sequencing platforms and experienced experts, the company is committed to providing efficient, economical, and accurate long-read sequencing services, including long-read sequencing library preparation, long-read sequencing, bioinformatics analysis, etc.

Contact Info:
Name: Kiko Garcia
Email: Send Email
Organization: CD Genomics
Website: https://www.cd-genomics.com/

Release ID: 89091147

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