NEW YORK, NY / ACCESSWIRE / June 21, 2019 /
Recently, in the face of market rumors the MGC TOKEN AONE technical team invited the media to have interview in the working center of MGC TOKEN AONE technical team for the first time.

The team leader of MGC TOKEN AONE warmly welcomed the reporters came to visit. The leader led the reporters to visit the main departments of MGC TOKEN. The leader firstly led the reporter to visit the customer service department, which is mainly responsible for dealing with the feedback emails from the official website of MGC TOKEN APP. They categorize the emails, respond to the feedbacks of the customers, sort out the feedbacks and submit them to the staffs of the technical department and the network maintenance department. Customer service department is the solid backing of technical department and network maintenance department. Technical department and network maintenance department adjust and update the system according to feedbacks from customer service department.

Then the reporter visited the technical department, which is divided into two parts. One is responsible for giving the optimal plan, the other is responsible for updating the system. The technical department have a tough work, who are the core of the whole MGC TOKEN and reliance of the whole system of MGC TOKEN to ensure stable operation.

With the guiding of leader, the reporter then came to the trading department. Trading department is mainly responsible for recording the market operation, including download and registrations amount of the APP, real-time fluctuations of MGC coin and market conditions. The trading department is the eye of the whole MGC TOKEN, who always paying attention to the latest developments of MGC TOKEN.

After visiting the trading department, the reporter came to the network maintenance department. The network maintenance department is mainly responsible for the minor problems of the system in daily operation and updating and maintaining system with colleagues of the technical department at emergency time. They are the logistics department of the whole MGC TOKEN.

Finally, the reporter came to the technical director’s office and interviewed the technical director.

Reporter: MGC TOKEN has encountered some difficulties recently. Have MGC TOKEN been systematically evaluated that whether such a long period of investment in R&D could conquer these difficulties or not?

Alfredo: It should be said that the problems we may encounter today have been predicted when we carried out R&D. We have been preparing for a long time. We are not totally hasty and unprepared to deal with this situation. These difficulties will have an impact on us, but not great impact. And there will be no major problems.

Reporter: In the current environment, how do you understand the significance of update for MGC TOKEN?

Alfredo: I think that science and technology are the common wealth of human beings. We must step on the shoulders of our predecessors, so that we can shorten the process of reaching the global leading position. As the frontier of block chain technology, only by constantly updating, could MGC TOKEN deals with the attacks from hackers all around the world easily. Science and technology are progressing, and our MGC TOKEN is also progressing.

Reporter: I would like to ask, what is MGC TOKEN’s worst plan for this incident?

Alfredo: We are not much influenced by the changes outside. Because we are confident that our products are better than others so that users have no better choices. Let me give you an example: How many wallets that can support so many mainstream currencies in the world? MGC TOKEN is the best one. There has been no application launched yet in the world, but MGC TOKEN has planned ahead of schedule. Among those who could do this in the world, there must have MGC TOKEN! Some people say that they want to invest in encrypted currency but could not realize due to lack of money, then how to deal with it? We MGC TOKEN offers a solution to this small group of investors with very low threshold so that we could give them enough opportunities. For those who defamed us, of course they can choose not to use our APP. Our technical breakthroughs not only create more opportunities for us in the market, but also bring more supports for survival. So we are not as worried as the outside imagines.

Reporter: For a long time, the most common accusation of token wallet is stealing intellectual property rights and changing in form but not in content. What do you think of this topic?

Alfredo: I can’t represent all token wallets, but only MGC TOKEN. In fact, token wallets are essentially the same. They are all developed based on block chain technology. The most important thing is innovation. We absolutely respect the intellectual property rights of other tokens, but our MGC TOKEN is definitely more innovative than other wallets.

Reporter: I have been a reporter in the UK for many years. In my impression, it is the first time that MGC TOKEN invited us to interview besides large events. Many media have said that it is a rare arrangement for MGC TOKEN to meet reporters today and it is to deal with the rare and special difficulties faced by MGC TOKEN. I wonder if you agree with this assessment? What message is the main purpose of this arrangement?

Alfredo: First of all, meeting with media is forced by the public relations department. They said that during this period, we should convey confidence to employees and hundreds of thousands of users, let them know more about us and trust us, and at the same time make the community relax. In fact, we did not encounter much difficulties. You may not have participated in our internal meetings. The meetings were full of excitement without any feeling of big problems. But the outside does not know, so we need to convey some confidence and let these leaders give a speech to make some efforts. So, meeting with the media is to convey a confidence to the community, and also to convey some beliefs to the Chinese market. We have not run away as some articles said. And we are still trying to update MGC TOKEN, please rest assured.

Reporter: What do you think is the main difficulty of MGC TOKEN?

Alfredo: We feel that except for difficulties, there are always difficulties. Nothing is not difficulty.

Reporter: Could you tell us something about international business? What are the plans for MGC TOKEN to expand the international business?

Alfredo: There has been no change. We will do as what did in the past. If you want to focus more on confidence, please pay attention to the meeting in Thailand on June 28th.

Reporter: What areas will MGC TOKEN focus on?

Alfredo: We will not change the current direction and enter those unfamiliar areas. At present, the security and stability of the system are still the main issues. Later, we will pay more attention to applications.

Reporter: Is the success of consumer business accidental?

Alfredo: As you all know, now is the era of block chain development. The world will become a block chain society. How does the block chain society perceive? It perceives with the application of block chain. So, the future of MGC TOKEN is still very bright. Wallet is only an area, and our goal is not limited to only this one.

Reporter: What do you want the fans of the global block chain to think about MGC TOKEN? What kind of image do you want MGC TOKEN to have overseas?

Alfredo: I think that the global block chain fans should have more patience and tolerance. MGC TOKEN is still at the early stage with many imperfections in many aspects. But we have been working hard. So, I hope all MGC TOKEN users can be a little more patient. I hope MGC TOKEN will have a better development in the world, which could become a leader in the era of block chain and the next “Bitcoin”.

Through this interview, we have known that even though MGC TOKEN has experienced setbacks, they did not take them into account from the attitude of leaders and staffs. We believe that they have already had a solution. Let’s look forward to the future development of MGC TOKEN!

mgctoken@gmail.com

SOURCE: MGC TOKEN

ReleaseID: 549442

NEW YORK, NY / ACCESSWIRE / June 21, 2019 /
During the updating period of MGC TOKEN system and internal personnel, MGC TOKEN staffs worked overtime to maintain the system in order to complete the system updating as soon as possible. And the MGC TOKEN customer service personnel also work overtime to process mail in order to meet customer needs in time.

In order to update the system as soon as possible and make MGC TOKEN much safer and MGC TOKEN APP more perfect, the technicians of MGC TOKEN worked overtime for day and night. Besides that, the staffs were also rushing to make new defense plans, constantly modifying and improving to provide the most perfect and highest quality solutions to the colleagues in charge of maintenance and updating. Leaders of MGC TOKEN often had meetings to communicate the details of system updates, and required the solution team to prepare solutions for emergencies in advance besides the current updating solutions.

During the maintenance and updating of MGC TOKEN APP, the MGC TOKEN staffs united as one. While giving the optimal plan, the technical team also allocated some personnel to carry out the maintenance and updating of the system. The colleagues in the administrative department actively dealt with the problems encountered by customers in the email. At the same time, they also recorded the needs of special customers, communicated with colleagues of the technical team and solved the feedback in customer emails. Leaders of MGC TOKEN often had meetings to negotiate in time, selected the best plan, asked the process and urged colleagues in the administrative department to update the official announcements in time so as to makes users understand the latest developments of MGC TOKEN.

All MGC TOKEN staffs gave full play to their position functions, provided strong technical support for MGC TOKEN, and made continuous efforts to make MGC TOKEN better and safer. The administrative department of MGC TOKEN has also become the solid backing of the technical department. While responding to customer emails in time, they also collated the feedback from users and submitted them to the technical department for processing.

With the unremitting efforts of all MGC TOKEN staffs, MGC TOKEN will become more perfect and safer to win this hard battle! We can’t make any update without hard workings of all the staffs. It is the common wish of all MGC TOKEN people to make MGC TOKEN safer and more effective. We believe that after this update, MGC TOKEN will win more trust of the clients.

mgctoken@gmail.com

SOURCE: MGC TOKEN

ReleaseID: 549440

NEW YORK, NY / ACCESSWIRE / June 21, 2019 /
Four years ago, the AONE technical team was established. Since then, the AONE team has gone through 1460 days and nights developed from nothing. At first, the team just research the development of block chain, then they successfully developed MGC TOKEN. During this period, AONE team went through a lot of hardships beyond imagination. In order to continue to show a better MGC TOKEN and have a better research on block chain technology, AONE team completely upgraded the LOGO!

The old logo of the AONE team, which has accompanied you for nearly four years, will no longer be used, and will be replaced by a more dynamic “MGC TOKEN-AONE” image. The new AONE LOGO not only represents the AONE team, but also symbolizes the inseparable relationship between MGC TOKEN and AONE team. M stands for MGC TOKEN and AONE stands for AONE team. MAONE not only means the inseparable relationship between MGC TOKEN and AONE team, but also indicates that MGC TOKEN will lead a new era of science and technology. From the LOGO full of sense of science and technology, we can see that MGC TOKEN and AONE technology team will not stop here. In the future, MGC TOKEN will be more secure and more in line with the trend of the times. The three-dimensional letters also indicate that MGC TOKEN will be more substantial, and MGC TOKEN will speed up launch of the applications.

In order to present a brand-new image of AONE team, we invited the first-class designers in the world to carry out brand positioning and style analysis. At the same time, we had several ideas of image design. After determining the final design direction, we made more than a dozen editions of design modifications and details improvement. After three months, “MGC TOKEN-AONE” was born.

Along with LOGO of AONE team, the team member of BG-MF and AONE team also updated. At the same time, MGC TOKEN APP system also updated. BG-MF and AONE team will work together with MGC TOKEN to present a new look in public.

In the future, BG-MF and AONE technology team will continue to make efforts to make MGC TOKEN a universal digital asset storage platform, and make the application not far away. It will create a global decentralized business financial ecosystem, which is just the beginning!

mgctoken@gmail.com

SOURCE: MGC TOKEN

ReleaseID: 549438

BISHOPSGATE, LONDON / ACCESSWIRE / June 21, 2019 / Further to the announcements on 30 May and 06 June 2019, SolGold confirms the Ecuadorean Constitutional Court has unanimously and definitively rejected the petition heard on 5 June 2019.

With this decision the petition has been closed and the case closed.

The Court rejected the petition on the basis of technicalities. The Court did not discuss, or rule on, the merits of the case. The formal resolution of the Court with further detail in to its rejection of the petition is yet to be published. SolGold will provide a further update in due course.

As advised in the Company’s earlier announcements, Constitutional submissions for a public hearing were received and heard in the Ecuadorean Constitutional Court on 5 June 2019 regarding the validity of the question proposed for a potential referendum regarding mining in the provinces in which SolGold’s 85% owned Cascabel project and other wholly owned exploration projects are located. Representatives from a large number of Ecuadorean government bodies, employees, regional community representatives, pro-mining groups, international mining groups as well as members of the community from Cascabel attended the hearing to demonstrate their strong opposition to the proposal. The Court heard arguments from many interested parties with the great majority opposing the proposed question.

The Cascabel project is a key project in Ecuador’s developing mining industry and a critical driver for the future of Ecuador’s economy in the view of the government. SolGold continues to receive full and objective support from the Ecuadorean government, who, most recently, publicly stated that Cascabel has the potential to become one of the world’s largest copper, silver and gold mines on 12 June 2019.

SolGold is committed to building an integrated explorer, appraiser and miner in the copper industry in Ecuador, and enjoys the support of its major shareholders, including Newcrest and BHP. SolGold is committed to the country’s economic development, provides employment and conducts responsible mining in line with local and international laws and standards.

SolGold recently announced findings from its Preliminary Economic Assessment (PEA) for the Alpala deposit at the Cascabel project in Northern Ecuador. The project indicated approximately US$17bn (at US$3.30/lb copper price and US$1,300oz gold price) in taxes, royalties and profit shares to the government and peoples of Ecuador.

The Company currently employs approximately 500 Ecuadoreans, and its staff is 97% Ecuadorean. The project will provide substantial and ongoing support for local, and a variety of, Ecuadorean industries and companies, and provide a platform for growth in the GDP of Ecuador. SolGold aims to replicate this project on other locations throughout the country as part of its plan to create a multigenerational company in Ecuador.

References to figures and tables relate to the version visible in PDF format by clicking the link below:

http://www.rns-pdf.londonstockexchange.com/rns/0060D_1-2019-6-21.pdf

CONTACTS

Nicholas
Mather
SolGold Plc (Chief Executive Officer)

nmather@solgold.com.au

Tel: +61 (0) 7 3303 0665

+61 (0) 417 880 448

Karl
Schlobohm
SolGold Plc (Company Secretary)

kschlobohm@solgold.com.au

Tel: +61 (0) 7 3303 0661

Anna Legge
SolGold Plc (Corporate Communications)

alegge@solgold.com.au

Tel: +44 (0) 20 3823 2131

Gordon Poole / Nick Hennis
Camarco (Financial PR / IR)

solgold@camarco.co.uk

Tel: +44 (0) 20 3757 4997

Andrew
Chubb / Ingo Hofmaier
Hannam & Partners (Joint Broker and Financial Advisor)

solgold@hannam.partners

Tel: +44 (0) 20 7907 8500

Ross
Allister / David McKeown
Peel Hunt (Joint Broker and Financial Advisor)

solgold@peelhunt.com

Tel: +44 (0)20 7418 8900

James
Kofman / Darren Wallace
Cormark Securities Inc. (Financial Advisor)

dwallace@cormark.com

Tel: +1 416 943 6411

Follow us on twitter @SolGold_plc

CAUTIONARY NOTICE

News releases, presentations and public commentary made by SolGold plc (the “Company”) and its Officers may contain certain statements and expressions of belief, expectation or opinion which are forward looking statements, and which relate, inter alia, to interpretations of exploration results to date and the Company’s proposed strategy, plans and objectives or to the expectations or intentions of the Company’s Directors. Such forward-looking and interpretative statements involve known and unknown risks, uncertainties and other important factors beyond the control of the Company that could cause the actual performance or achievements of the Company to be materially different from such interpretations and forward-looking statements.

Accordingly, the reader should not rely on any interpretations or forward-looking statements; and save as required by the exchange rules of the TSX and LSE or by applicable laws, the Company does not accept any obligation to disseminate any updates or revisions to such interpretations or forward-looking statements. The Company may reinterpret results to date as the status of its assets and projects changes with time expenditure, metals prices and other affecting circumstances.

This release may contain “forward‑looking information” within the meaning of applicable Canadian securities legislation. Forward‑looking information includes, but is not limited to, statements regarding the Company’s plans for developing its properties. Generally, forward‑looking information can be identified by the use of forward-looking terminology such as “plans”, “expects” or “does not expect”, “is expected”, “budget”, “scheduled”, “estimates”, “forecasts”, “intends”, “anticipates” or “does not anticipate”, or “believes”, or variations of such words and phrases or state that certain actions, events or results “may”, “could”, “would”, “might” or “will be taken”, “occur” or “be achieved”.

Forward‑looking information is subject to known and unknown risks, uncertainties and other factors that may cause the actual results, level of activity, performance or achievements of the Company to be materially different from those expressed or implied by such forward‑looking information, including but not limited to: transaction risks; general business, economic, competitive, political and social uncertainties; future prices of mineral prices; accidents, labour disputes and shortages and other risks of the mining industry. Although the Company has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking information, there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no assurance that such information will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward‑looking information. The Company does not undertake to update any forward-looking information, except in accordance with applicable securities laws.

The Company and its officers do not endorse, or reject or otherwise comment on the conclusions, interpretations or views expressed in press articles or third-party analysis, and where possible aims to circulate all available material on its website.

The Company recognises that the term “World Class” is subjective and for the purpose of the Company’s projects the Company considers the drilling results at the growing Alpala Porphyry Copper Gold Deposit at its Cascabel Project to represent intersections of a “World Class” deposit. The Company considers that “World Class” deposits are rare, very large, long life, low cost, and are responsible for approximately half of total global metals production.

“World Class” deposits are generally accepted as deposits of a size and quality that create multiple expansion opportunities, and have or are likely to demonstrate robust economics that ensure development irrespective of position within the global commodity cycles, or whether or not the deposit has been fully drilled out, or a feasibility study completed.

Standards drawn from industry experts (1) Singer and Menzie, 2010; (2) Schodde, 2006; (3) Schodde and Hronsky, 2006; (4) Singer, 1995; (5) Laznicka, 2010) have characterised “World Class” deposits at prevailing commodity prices. The relevant criteria for “World Class” deposits, adjusted to current long run commodity prices, are considered to be those holding or likely to hold more than 5 million tonnes of copper and/or more than 6 million ounces of gold with a modelled net present value of greater than USD 1 Billion.

The Company and its external consultants prepared an initial mineral resource estimate at the Cascabel Project in December 2017. Results are summarised in Table B attached.

The Mineral Resource Estimate was completed from 53,616m of drilling, approximately 84% of 63,500m metres drilled as of mid-December 2017, the cut-off date for the maiden resource calculation. There remains strong potential for further growth from more recent drilling results, and continue rapid growth of the deposit.

Any development or mining potential for the project remains speculative.

Drill hole intercepts have been updated to reflect current commodity prices, using a data aggregation method, defined by copper equivalent cut-off grades and reported with up to 10m internal dilution, excluding bridging to a single sample. Copper equivalent grades are calculated using a gold conversion factor of 0.63, determined using an updated copper price of USD3.00/pound and an updated gold price of USD1300/ounce. True widths of down hole intersections are estimated to be approximately 25-70%.

On the basis of the drilling results to date and the results of the Alpala Maiden Mineral Resource Estimate, the reference to the Cascabel Project as “World Class” (or “Tier 1”) is considered to be appropriate. Examples of global copper and gold discoveries since 2006 that are generally considered to be “World Class” are summarised in Table
A.

References cited in the text:

1.

Singer, D.A. and Menzie, W.D., 2010. Quantitative
Mineral Resource Assessments: An Integrated Approach. Oxford University Press Inc.

2.

Schodde, R., 2006. What do we mean by a world class
deposit? And why are they special. Presentation. AMEC Conference, Perth.

3.

Schodde, R and Hronsky, J.M.A, 2006. The Role of
World-Class Mines in Wealth Creation. Special Publications of the Society of Economic Geologists Volume 12.

4.

Singer, D.A., 1995, World-class base and precious metal
deposits-a quantitative analysis: Economic Geology, v. 90, no.1, p. 88-104.

5.

Laznicka, P., 2010. Giant Metallic Deposits: Future
Sources of Industrial Metal, Second Edition. Springer-Verlag Heidelberg.

Deposit
Name

Discovery
Year

Major
Metals

Country

Current
Status

Mining
Style

Inventory

LA COLOSA

2006

Au, Cu

Colombia

Feasibility – New Project

Open Pit

1 469Mt @ 0.95g/t Au; 14.3Moz Au

LOS SULFATOS

2007

Cu, Mo

Chile

Advanced Exploration

Underground

2 1.2Bt @1.46% Cu & 0.02% Mo; 17.5Mt Cu

BRUCEJACK

2008

Au

Canada

Development/Construction

Open Pit

3 15.6Mt @ 16.1 g/t Au; 8.1Moz Au

KAMOA-KAKULA

2008

Cu, Co, Zn

Congo (DRC)

Feasibility – New Project

Open Pit & Underground

4 1.3Bt @ 2.72% Cu; 36.5 Mt Cu

GOLPU

2009

Cu, Au

PNG

Feasibility – New Project

Underground

5 820Mt @ 1.0% Cu, 0.70g/t Au; 8.2Mt Cu, 18.5Moz Au

COTE

2010

Au, Cu

Canada

Feasibility Study

Open Pit

6 289Mt @ 0.90 g/t Au; 8.4Moz Au

HAIYU

2011

Au

China

Development/Construction

Underground

7 15Moz Au

RED HILL-GOLD RUSH

2011

Au

United States

Feasibility Study

Open Pit & Underground

8 47.6Mt @ 4.56 g/t Au; 7.0Moz Au

XILING

2016

Au

China

Advanced Exploration

Underground

9 383Mt @ 4.52g/t Au; 55.7Moz Au

Source: after MinEx Consulting, May
2017

1 Source:
http://www.mining‐technology.com/projects/la‐colosa

2 Source:
http://www.angloamerican.com/media/press‐releases/2009

3 Source:
http://www.pretivm.com/projects/brucejack/overview/

4 Source:
https://www.ivanhoemines.com/projects/kamoa‐kakula‐project/

5 Source:http://www.newcrest.com.au/media/resource_reserves/2016/December_2016_Resources_and_Reserves_Statement.pdf

6 Source:
http://www.canadianminingjournal.com/news/gold‐iamgold‐files‐cote‐project‐pea/

7 Source:
http://www.zhaojin.com.cn/upload/2015‐05‐31/580601981.pdf

8 Source:
https://mrdata.usgs.gov/sedau/show‐sedau.php?rec_id=103

9 Source:
http://www.chinadaily.com.cn/business/2017‐03/29/content_28719822.htm

Table A: Tier 1 global copper and gold discoveries since 2006. This table does not purport to be exhaustive exclusive or definitive.

Grade

Category

Resource

Category

Tonnage

(Mt)

Grade

Contained Metal

Cu (%)

Au (g/t)

CuEq (%)

Cu (Mt)

Au (Moz)

CuEq (Mt)

Total >0.2% CuEq

Indicated

2,050

0.41

0.29

0.60

8.4

19.4

12.2

Inferred

900

0.27

0.13

0.35

2.5

3.8

3.2

Table B: Alpala Mineral Resource Estimate updated effective 16 November 2018.

Notes:

•

Mr. Martin Pittuck, MSc, CEng, MIMMM, is responsible for this Mineral Resource estimate and is an “independent qualified person” as such term is defined in NI 43-101.

•

The Mineral Resource is reported using a cut-off grade of 0.3% copper equivalent calculated using [copper grade (%)] + [gold grade (g/t) x 0.6] based on a copper price of US$2.8/lb and gold price of US$1,160/oz.

•

The Mineral Resource is considered to have reasonable potential for eventual economic extraction by underground mass mining such as block caving.

•

Mineral Resources are not Mineral Reserves and do not have demonstrated economic viability.

•

The statement uses the terminology, definitions and guidelines given in the CIM Standards on Mineral Resources and Mineral Reserves (May 2014).

•

The MRE is reported on 100 percent basis.

•

Values given in the table have been rounded, apparent calculation errors resulting from this are not considered to be material.

•

The effective date for the Mineral Resource statement is 16 November 2018.

This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.

SOURCE: SolGold PLC

ReleaseID: 549434

Leading Cancer Centre Demonstrates Use of Parsortix as a Liquid Biopsy to Investigate Key Immunotherapy Target in Lung Cancer

Potential for use of Parsortix as treatment selection biomarker in assessing patient response to cancer immunotherapy drugs with revenues forecast to exceed US$ 20 billion this year

Lung cancer is a key target for liquid biopsy with up to 24% of patients experiencing complications from traditional tissue biopsy and many biopsies failing to yield tissue that can be analysed

GUILDFORD, SURREY / ACCESSWIRE / June 21, 2019 / ANGLE plc (AIM: AGL OTCQX: ANPCY), a world-leading liquid biopsy company, is delighted to announce that leading European cancer centre, University Medical Centre Hamburg-Eppendorf (UKE) has published results of work demonstrating that ANGLE’s ParsortixTM system can be used as a liquid biopsy to investigate programmed death-ligand 1 (PD-L1) status in non small cell lung cancer (NSCLC) patients.

Expression of the protein PD-L1 in cancer cells is of particular importance as PD-L1, and PD-1 the protein to which it binds, are the key targets for leading immunotherapy drugs, with revenues forecast to exceed US$ 20 billion in 2019. Immunotherapy drugs can be very effective for some patients. However, typically only 20-30% of patients will respond and it is crucial to be able to accurately identify which patients, both to reduce the patient’s exposure to unnecessary drug toxicity and to reduce unnecessary healthcare expenditure, given such treatment can cost around US$150,000 per patient each year and only a minority of patients benefit.

The research by UKE undertaken using Parsortix over a three year period and published in Cancers, a renowned peer-reviewed medical journal, shows that in a head-to-head comparison of 97 lung cancer patients, Parsortix was able to detect circulating tumor cells (CTCs) in nearly twice as many patients as the leading competing system. Furthermore, the research showed that the PD-L1 expression in a tissue biopsy (the current standard of care, which is invasive and expensive) does not always reflect the heterogeneity of PD-L1 expression in the cancer of Stage IV NSCLC patients with multiple tumor sites and a Parsortix CTC liquid biopsy could therefore provide more comprehensive information.

A longitudinal investigation using Parsortix in NSCLC patients (n=11) being treated with immunotherapy drugs Pembrolizumab (Keytruda – Merck & Co), Nivolumab (Opdivo – Bristol-Myers Squibb) or Atezolizumab (Tecentriq – Roche Genentech) over multiple time points, investigated the changes in PD-L1 positive and negative circulating tumor cells (CTCs). In all the NSCLC patients that developed resistance to these immunotherapies (n=5), i.e. patients stopped responding to the drug or did not respond to the drug, an increase in PD-L1+ CTCs was identified compared to earlier time points.

UKE’s success in using Parsortix for PD-L1 analysis in NSCLC is consistent with work previously published demonstrating the use of Parsortix for PD-L1 analysis in head and neck squamous cell carcinoma (HNSCC) and we would anticipate that Parsortix could be used for PD-L1 analysis in multiple other cancer types. Keytruda, for example, is a broad spectrum anti-cancer drug and has already been approved for 15 cancers and 10 tumor types.

Tissue biopsy in the lung, both for lung cancer and as a common metastatic site, is challenging and carries significant risk with up to 24% of patients experiencing serious complications and up to 1% resulting in death. Further the tissue biopsy is expensive, impractical for repeat testing and a significant proportion of biopsies fail to provide sufficient quality or quantity of tissue for accurate analysis. The Parsortix CTC liquid biopsy has the potential to address these limitations through a simple blood test. The ctDNA liquid biopsy approach (fragments of DNA from dead cancer cells) used by a number of large scale laboratories cannot analyse PD-L1 as this is a protein expression on the cancer cells.

Lung cancer has the highest incidence and mortality rate of all cancers (World Cancer Factsheet 2018: 2.1 million new cancer cases and 1.8 million deaths per annum).

ANGLE believes there is an opportunity to build on the work undertaken to provide services to pharmaceutical drug trials in determining likely patient responders and as a companion diagnostic to assess which patients are likely to respond to particular immunotherapies.

ANGLE’s Founder and Chief Executive, Andrew Newland, commented:

“The ability to identify which patients will respond to PD-L1/PD-1 immunotherapies and to assess response to these drugs during treatment, is a major unmet medical need. The Parsortix system addresses key shortcomings in alternative approaches offering the potential for routine liquid biopsies through a simple blood test.”

A copy of the Cancers publication is available on ANGLE’s website here:

https://angleplc.com/library/publications/.

For further information ANGLE:

ANGLE plc

+44 (0) 1483 343434

Andrew Newland, Chief Executive

Ian Griffiths, Finance Director

finnCap Ltd (NOMAD and Joint Broker)

Corporate Finance – Carl Holmes, Simon Hicks,

Max Bullen-Smith

ECM – Alice Lane, Sunila de Silva

+44 (0)20 7220 0500

WG Partners (Joint Broker)

Nigel Barnes, Nigel Birks, Andrew Craig, Chris Lee

+44 (0) 203 705 9330

FTI Consulting

Simon Conway, Ciara Martin

Matthew Ventimiglia (US)

+44 (0) 203 727 1000

+1 (212) 850 5624

The information communicated in this
announcement is inside information for the purposes of Article 7 of Regulation
596/2015.

For Frequently Used Terms, please see the Company’s website on http://www.angleplc.com/the-parsortix-system/glossary/

Notes for editors

About ANGLE plc www.angleplc.com

ANGLE is a world leading liquid biopsy company with sample-to-answer solutions. ANGLE’s proven patent protected platforms include an epitope-independent circulating tumor cell (CTC) harvesting technology and a downstream analysis system for cost effective, highly multiplexed analysis of nucleic acids and proteins.

ANGLE’s cell separation technology is called the Parsortix
TM system, and it enables a liquid biopsy (a simple blood test) to be used to provide the cells of interest to the user in a format suitable for multiple downstream subsequent analyses. CTCs enable the complete picture of a cancer to be seen as they allow DNA, RNA and protein analysis and the live cells harvested can be cultured. The Parsortix technology is the subject of 24 granted patents in Europe, the United States, China, Australia, Canada, India, Japan and Mexico with three extensive families of patents are being progressed worldwide. The system is based on a microfluidic device that captures cells based on a combination of their size and compressibility. The Parsortix system has a CE Mark in Europe for the indicated use and FDA clearance is in process for the United States with a 400 subject study in metastatic breast cancer. ANGLE is seeking to be the first ever FDA cleared CTC harvesting system and only the third ever FDA cleared liquid biopsy test. ANGLE has already undertaken two separate 200 subject clinical studies under a program designed to develop an ovarian cancer pelvic mass triage test, with the results showing best in class accuracy (ROC-AUC) of 95.1%. The pelvic mass triage assay has undergone further refinement and optimisation, and is currently in the process of a clinical verification study.

ANGLE’s technology for the multiplex evaluation of proteins and nucleic acids of all types is called the HyCEADTM Ziplex® platform and is based on a patented flow through array technology. It provides for low cost, highly multiplexed, rapid and sensitive capture of targets from a wide variety of sample types. A proprietary chemistry approach (the HyCEAD method) allows for the capture and amplification of over 100 biomarkers simultaneously in a single reaction. The HyCEAD Ziplex system is ideal for measuring gene expression and other markers directly from Parsortix harvests and was used in the ovarian cancer pelvic mass triage test to achieve best in class accuracy (ROC-AUC) of 95.1%.

ANGLE’s proprietary technologies can be combined to provide automated, sample-to-answer results in both centralised laboratory and point-of-use cartridge formats.

ANGLE has established formal collaborations with world-class cancer centres and major corporates such as Abbott, Philips and QIAGEN, and works closely with leading CTC translational research customers. These Key Opinion Leaders (KOLs) are working to identify applications with medical utility (clear benefit to patients), and to secure clinical data that demonstrates that utility in patient studies. The body of evidence as to the benefits of the Parsortix system is growing rapidly from our own clinical studies in metastatic breast cancer and ovarian cancer and also from KOLs with 21 peer-reviewed publications and numerous publicly available posters, available on our website.

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SOURCE: ANGLE plc

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