Monthly Archives: August 2019

Global Speech and Voice Recognition Market 2019 Analysis by Size, Share, Demand, Latest Trends, Emerging-Technologies, Investment-Opportunities and Forecast to 2023

Speech and Voice Recognition industry research report presented by Orbis Research is comprehensive overview of present market scenario and future growth prospects, this data is very useful to judge and understand the business dynamics and to get competitor analysis as well.

Dallas, United States – August 31, 2019 /MarketersMedia/ —

The research report on the topic of Speech and Voice Recognition, gives a comprehensive study of various factors of the Speech and Voice Recognition market. The Speech and Voice Recognition market report is created and written keeping in consideration various important factors. The reports are written after an in depth market study and analysis. It testifies the constant growth in the Speech and Voice Recognition market, in spite of the current unsteady market scenario in terms of revenue. The report is structured and is well written by industry experts. The report covers important information about various vendors, manufacturers, research papers and many similar important facts and features.

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In the recent years, the Speech and Voice Recognition market has seen growth to USD XXX million and is predicted to grow more during the coming year. The report gives a detailed summary of the market trends, shares and patterns of revenue growth and the market value. The market research document on Speech and Voice Recognition is written post extensive research and findings based on it. The report gives an in-depth study of producers that are supplying the market. With the help of this report knowledge about the market and its key players can be gained for those wanting to enter the market. Furthermore, the report shall give you a detailed list of competitive analysis and it would give you a detailed report on the various market strategies, models and growth pattern in terms of revenue of the competitors. Market segmentation, forecast and other factors of the business which gives a qualitative and quantitative view of the market. Anyone thinking of investing in a new business, needs to have a look at the Speech and Voice Recognition market report to judge and understand the business dynamics at the same time get competitor analysis.

Key Manufacturers:
• NUANCE COMMUNICATIONS
• MICROSOFT
• ALPHABET
• SENSORY
• CANTAB RESEARCH
• READSPEAKER HOLDING
• PARETEUM
• IFLYTEK
• VOICEVAULT
• VOICEBOX TECHNOLOGIES
• LUMENVOX
• ACAPELA GROUP

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The growth of business is dependent on its various segments and the report covers all the possible segments of the business. The report gives you a detailed view of the various market segments based on type, application, geography and other relevant features. The report will help the readers understand the behavior pattern of the consumers towards a product category or the overall market. Region wise segmentation is an integral part of the market report and is done in this market report. The report gives a detailed study about the various regional segments of the market along with an overview of the largest market contributors. The report will give you a summary of business opportunities and revenue prospects over the forecast period and corresponding growth driving factors. For organizations or businesses looking for growth opportunity by undergoing changes that would positively impact the business, segmentation helps in understanding the market dynamics.
Segmentation types included in this report are:
Product Type Segmentation
• Speech Recognition
• Voice Recognition
Industry Segmentation
• Government
• Retail
• Medical
• Military
• Legal
Channel (Direct Sales, Distributor) Segmentation

The Speech and Voice Recognition report will cover the main region and share information about the market size and value in the particular region. The report also have similar information for other regional segmentation.
Region Segmentation
• North America Country (United States, Canada)
• South America
• Asia Country (China, Japan, India, Korea)
• Europe Country (Germany, UK, France, Italy)
• Other Country (Middle East, Africa, GCC)

The detailed report on Speech and Voice Recognition, is a document that gives you a detailed understanding of the market at the same time ensuring that the reader can understand all the parameters effecting the market and are important. The report is ideal if reader is looking for a detailed study about the market parameters that influence the market growth.

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Some Major Points from Table of Content are:
Section 1 Speech & Voice Recognition Product Definition
Section 2 Global Speech & Voice Recognition Market Manufacturer Share and Market Overview
Section 3 Manufacturer Speech & Voice Recognition Business Introduction
Section 4 Global Speech & Voice Recognition Market Segmentation (Region Level)
Section 5 Global Speech & Voice Recognition Market Segmentation (Product Type Level)
Section 6 Global Speech & Voice Recognition Market Segmentation (Industry Level)
Section 7 Global Speech & Voice Recognition Market Segmentation (Channel Level)
Section 8 Speech & Voice Recognition Market Forecast 2018-2023
Section 9 Speech & Voice Recognition Segmentation Product Type
Section 10 Speech & Voice Recognition Segmentation Industry
Section 11 Speech & Voice Recognition Cost of Production Analysis
Section 12 Conclusion

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Orbis Research (orbisresearch.com) is a single point aid for all your market research requirements. We have vast database of reports from the leading publishers and authors across the globe. We specialize in delivering customized reports as per the requirements of our clients. We have complete information about our publishers and hence are sure about the accuracy of the industries and verticals of their specialization. This helps our clients to map their needs and we produce the perfect required market research study for our clients.

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Source: MarketersMedia

Release ID: 88914166

Global Building Information Modeling Market 2019 Overview by Companies, Revenue Generation, Increasing Demand, Key Strategies and Rapid Growth till 2024

Building Information Modeling industry research report provides in depth analysis of market size, share, current trends, company competition, regional demand comparison and sales & consumption status upto 2024.

Dallas, United States – August 31, 2019 /MarketersMedia/ —

BIM (Building Information Modeling) is an intelligent 3D model-based process that gives architecture, engineering, and construction (AEC) professionals the insight and tools to more efficiently plan, design, construct, and manage buildings and infrastructure. Building Information Modeling market was accounted for USD xxx million in the historical year and is estimated to reach at USD xxx million by the end of the forecast period, rising at a CAGR of xx%. The study on global Building Information Modeling market, offers deep insights about the Building Information Modeling market covering all the crucial aspects of the market. Some of the important aspects analyzed in the report includes market share, production, key regions, revenue rate as well as key players. This Building Information Modeling report also provides the readers with detailed figures at which the Building Information Modeling market was valued in the historical year and its expected growth in upcoming years. Besides, analysis also forecasts the CAGR at which the Building Information Modeling is expected to mount and major factors driving market’s growth.

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Market research reports play an extremely important role in refining the productivity of an industry. The information in this reports will help the companies to make informed marketing strategies. Moreover, ultimate goal of market research is to analyze how the market’s target group will obtain a product or service. Market research report is predominantly prepared following certain methodology and guidelines for collecting, organizing and analyzing data. The research report on global Building Information Modeling market has been very well drafted for the benefit of the readers who are looking forward to invest in the market.

Major Players included in this industry are:
• Autodesk, Inc (US)
• Nemetschek AG (Germany)
• Bentley Systems, Inc (US)
• Trimble Navigation Ltd (US)
• Dassault Systemes S.A. (France)
• RIB Software AG (Germany)
• Robert Mcneel & Associates (US)
• Cadsoft Corporation (US)
• Siemens (Germany)
• AVEVA Group (UK)
• Aconex (Australia)
• Beck Technology (US)
• Inovaya (US)
• Synchro (UK)
• IES (UK)
• Hongye Technology (China)
• Beijing Explorer Software (China)
• Lubansoft (China)
• Glodon(China)
• PKPM (China)

Besides, focusing on overall aspects of the market this report majorly covered profiles of the top big companies along with their sales data, etc. It also delivers the business models, strategies, growth, innovations and every information about key manufacturers that will enable in making business estimates. In addition, every market has a set of manufacturers, vendors and consumers that define the market as well as their every moves and achievements becomes a subject of studying for market analysts.

Browse Complete Global Building Information Modeling Market Report at:
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Market research report on the global Building Information Modeling market, also has the market analyzed on the basis of different end user applications and type. End user application segments analysis allows defining the consumer behavior as well. It is helpful to investigate product application in order to foretell the products outcome. Analyzing different segment type is also crucial aspect. It helps determine which type of the product or service needs improvement. When reports are product centric, they also includes information about sales channel, distributors, traders as well as dealers. This facilitates effective planning as well as execution of the supply chain management. In a nutshell, a market research report is through guide of a market that aids the better marketing and management of businesses.

Product Type Coverage (Market Size & Forecast, Major Company of Product Type etc.):
• 3D BIM management of design models
• 4D BIM management of schedule
• 5D BIM management of costs
Application Coverage (Market Size & Forecast, Different Demand Market by Region, Main Consumer Profile etc.):
• Architects
• AEC engineering offices
• Contractors
• Owners
• Others

Moreover, reports offers market competition through region segmentation of markets that enables in thorough analysis of the market in terms of revenue generation potential, demand & supply comparison, business opportunities and future estimates of the market. The annual progression for the global Building Information Modeling market in different regions cannot always be listed down as it will keep changing, thus studying and reviewing markets occasionally becomes vital. Major regions highlighted for the global Building Information Modeling market report, include North America, South America, Asia, Europe and Middle East.

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Contact Info:
Name: Hector Costello
Email: Send Email
Organization: Orbis Research
Address: Hector Costello Senior Manager – Client Engagements 4144N Central Expressway, Suite 600, Dallas, Texas – 75204, U.S.A. Phone No.: +1 (214) 884-6817; +912064101019
Phone: +1 (214) 884-6817
Website: https://www.orbisresearch.com/reports/index/global-building-information-modeling-bim-market-status-2015-2019-and-forecast-2020-2024-by-region-product-type-and-end-use

Source URL: https://marketersmedia.com/global-building-information-modeling-market-2019-overview-by-companies-revenue-generation-increasing-demand-key-strategies-and-rapid-growth-till-2024/88914179

Source: MarketersMedia

Release ID: 88914179

Montgomery County TX Realtor Expy Award, most Cutting Edge Agent Nationwide

Best Priced Properties has launched an updated home sale service to help home sellers earn up to 18% more money anyone moving to the Houston save thousands on your home purchase.The team is comprised of real estate specialists with over 27 years’ experience

Spring, United States – August 31, 2019 /PressCable/ —

Best Priced Properties has launched an updated home sale service for home buyers in the Houston area. Anyone looking to move to Houston can now buy a home with zero down payment and no closing cost, making the buying process easier and more streamlined.

More information can be found at: https://bestpricedproperties.com

More and more people have been moving to Houston in recent years, making it one of the fastest growing big cities in the US. It is ranked fourth in total population, and is known for its modern business, range of restaurants, and diverse communities.

One of the things drawing residents to the area is that it has a 26% lower average living cost than the top 20 metro average. In addition to this, it is a culturally vibrant city and offers living opportunities for any lifestyle.

Best Priced Properties has now updated its real estate services for anyone looking to move to the Houston area. Interested parties can browse available properties using the on-site search engine, which currently has over 29,000 houses, 4,000 condos and 400 multi-family listings.

The Best Priced Properties team is made up of full time realtors and native Houstonians, who are trained in sales and marketing. They also have 27 years of real estate experience and own a Digital Marketing Agency to help there clients sell their home faster for more money.

They specialize in buying and selling new construction, luxury residential, relocation, first time buyer and residential resale properties in Montgomery County and N. Harris County, Texas.

The company states: “Whether you are buying, selling or investing in residential or commercial real estate, we possess the proven experience and resources which have allowed them to help their clients achieve their real estate goals. As always our clients are first and we strongly believe that integrity and constant communication are essential to achieving a win-win for all parties involved.”

Interested parties will find the full range of available properties on the URL above.

Contact Info:
Name: Russell & Melissa Banki
Email: Send Email
Organization: Best Priced Properties
Address: 330 Rayford Road STE #112, Spring, TX 77386, United States
Phone: +1-936-445-0216
Website: https://www.bestpricedproperties.com

Source: PressCable

Release ID: 88914049

Charleston Bachelorette Parties Boat Tours Sunset Cruise Services Launched

Charleston, SC boat tour agency Carolina Marine Group announced the launch of its tours with spacious, fully equipped boats for unique bachelorette parties.

Charleston, United States – August 31, 2019 /PressCable/ —

Carolina Marine Group, a boat tour agency based in Charleston, South Carolina, announced the launch of their an updated range of services for clients interested in unique bachelorette parties on a spacious and luxurious party boats. The company has two boats available for bachelorette parties. Their party boat can perfectly accommodate groups of up to 18 people, fully equipped with a variety of amenities to ensure an unforgettable experience.

More details can be found at https://carolinamarinegroup.com/weddings-bachelorette-parties

The newly launched tours are available in Charleston, a popular destination for bachelor and bachelorette parties. The new updated tours service a particular need. While small groups find it easy to get a bachelorette party on the water, larger groups typically don’t consider the option due to the USCG regulations limiting boats to 6 people or less.

Carolina Marine Group is one of the few boat tour agencies capable of accommodating up to 18 guests, its large Ship of Fools party boat being ideal for larger groups looking for a unique bachelorette party. The large, stable party boat is fully equipped with a big swim platform and boarding ladder for easy access, as well as a large cooler to keep refreshments fresh.

Smaller groups can opt for the Hatteras, a spacious convertible boat which can comfortable accommodate up to six guests. The boat features a large open deck for dancing and partying, as well as a fridge, comfortable chairs and couches, and other amenities.

Carolina Marine Group also provides a variety of cruises and tours, including romantic sunset cruises, dolphin tours and many others.

A satisfied client said: “We had such a fun and great experience! We booked with Captain Dave of Carolina Marine Group for a bachelorette party and could not have had a better time! Captain Dave made sure we had everything we needed and gave us plenty of time to swim and sight see. We’re so glad we found Carolina Marine Group!”

Interested parties can find more information by visiting the above-mentioned website.

Contact Info:
Name: Dave Gugliotti
Email: Send Email
Organization: Carolina Marine Group
Address: 17 Lockwood Drive, Charleston, SC 29401, United States
Phone: +1-843-779-5711
Website: https://www.carolinamarinegroup.com

Source: PressCable

Release ID: 88913031

Is “Cheap” Really Good When It Comes To Car Insurance?

LOS ANGELES, CA / ACCESSWIRE / August 31, 2019 / Compare-autoinsurance.org has launched a new blog post that presents several disadvantages of cheap car insurance policies.

For more info and free car insurance quotes online, visit https://compare-autoinsurance.org/the-disadvantages-of-cheap-car-insurance-policies/

Everyone strives to obtain the cheapest car insurance possible. However, getting a cheap car insurance policy has several disadvantages. Policyholders that own cheap car insurance will have to face some tough consequences if they are required to file a claim.

The disadvantages of a cheap car insurance policy are the following:

The coverage can’t be enough. The liability coverage has some really low limits. While experts are recommending to have at least $500,000 of liability coverage per accident and $2 million to be fully protected, cheap policies are offering only $10,000 to $30,000 liability coverage per incident. These small limits can easily be exceeded even in a minor accident with a few passengers that require costly medical treatments.
Drivers won’t be able to fix their cars after a collision. Insurance companies will cover the damage inflicted on other drivers, property, passengers, and vehicles if the policyholder only has liability coverage. Liability coverage does not cover the costs to repair the policyholder’s damaged vehicle.
Drivers can remain without their cars after a claim. Drivers that have cheap car insurance are more likely to remain without a car after filing a claim. Policyholders that don’t have the money to repair their vehicles after a crash, and their cheap policies don’t cover the costs will probably remain without their cars until they can afford to repair them.
Bad customer service. Some insurers will offer better customer support to persons that have expensive policies compared to those that have only liability coverage. Although this doesn’t sound that bad, drivers that are dealing with an insurance claim will need to have good customer support.
High deductible. Raising the deductible is one of the most common methods used to lower the insurance premiums. Drivers will pay less on their monthly insurance, but if they are required to make a claim, will have to pay a significant amount of money upfront before the insurance kicks

For additional info, money-saving tips and free car insurance quotes, visit https://compare-autoinsurance.org/

Compare-autoinsurance.org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc.

“Most drivers want to obtain the cheapest car insurance. However, cheap car insurance policies have several disadvantages that will make drivers think twice before getting cheap insurance ”, said Russell Rabichev, Marketing Director of Internet Marketing Company.

CONTACT:

Company Name: Internet Marketing Company
Person for contact Name: Gurgu C
Phone Number: (818) 359-3898
Email: cgurgu@internetmarketingcompany.biz
Website: https://compare-autoinsurance.org/

SOURCE: Internet Marketing Company

ReleaseID: 558109

Dipeptidyl Peptidase 3 (DPP3) Cause of Acute Myocardial Depression. Sphingotec Launches First IVD Test For DPP3 on Nexus IB10 Point-of-Care Platform

PARIS, FRANCE, and HENNIGSDORF/BERLIN, GERMANY / ACCESSWIRE / August 31, 2019 / Diagnostics company SphingoTec GmbH (“sphingotec”, Hennigsdorf near Berlin, Germany) today launched IB10 sphingotest(R) DPP3, the first CE-IVD-marked point-of-care biomarker test able to quantify DPP3 blood-plasma levels, a novel and unique biomarker predicting outcomes in patients with cardiogenic shock at admission to intensive care units (ICUs). The DPP3 biomarker indicates angiotensin II and enkephalin signaling pathway disruptions leading to acute, short-term organ dysfunction. sphingotec will make the test initially available to the critical care community for further assessment of the clinical utility of the DPP3biomarkerin critical care settings. The assay is designed and validated for use with sphingotec’s fully automated Nexus IB10 whole blood point-of-care platform for rapid testing in laboratories, emergency departments and intensive care units together with a menu of standard critical care tests also available on the Nexus IB10 instrument.

sphingotec launched the very first CE-marked IVD assay for Dipeptidyl Peptidase 3 (DPP3), a novel biomarker able to assess outcomes in patients with cardiogenic shock at admission for further clinical validation through the critical care community

IB10 sphingotest(R) DPP3 is now available on sphingotec’s proprietary automated Nexus IB10 point-of-care platform and quantitatively measures levels of circulating DPP3 inwhole blood and plasma samples

Data presented by Prof. Alexandre Mebazaa at ESC Congress 2019 in Paris provide evidence for a novel disease mechanism in which circulating DPP3 has a causal role in cardiac and renal dysfunction

Further results presented by Prof. Mebazaa demonstrate that effects of pathological concentrations of DPP3 were immediately reversed in pre-clinical disease models upon injection of Procizumab, an anti-DPP3-antibody in preclinical development by 4TEEN4 Pharmaceuticals

sphingotec has in-licensed global rights to distribute DPP3 on Nexus IB10 from 4TEEN4 Pharmaceuticals GmbH for diagnostic purposes in multiple indications

The novel DPP3 test complements sphingotec’s portfolio of IVD tests for acute care biomarkers, including vascular function marker bio-ADM(R)and kidney function marker penKid(R),designed to support decision making at ICUs and EDs

DPP3 is at the core of a novel disease mechanism presented by Prof. Alexandre Mebazaa (Hôpital Lariboisière, Paris) today at ESC Congress 2019 (organised by the European Society of Cardiology ESC, Paris) and was described in detail in two high-ranking peer-reviewed publications by Prof. Mebazaa and co-workers also published today1,2.Results from independent clinical studies provide evidence that outcomes of patients with cardiogenic shock are associated with DPP3 blood concentrations. The scientists hypothesize that DPP3 is released from cells into the bloodstream upon cell death and degrades central mediators of cardiovascular function, angiotensin II as well as kidney function mediator enkephalin.

In blood samples from patients with cardiogenic shock enrolled in the OptimaCC3(N=57) and the CardShock4 (174 patients) studies, sustained high or increasing DPP3 plasma levels were associated with a significantly reduced cardiac left ventricular ejection fraction, impaired kidney function, and a markedly increased risk of mortality while decreasing levels of DPP3 were associated with higher survival. The causal role of DPP3 was further substantiated by studies in pre-clinical models in which injection of DPP3 impaired heart and kidney function. All these effects were immediately reversed in vivo following administration of the pre-clinical stage anti-DPP3 antibody Procizumab in a severe acute heart failure model. Procizumab is developed by the biopharmaceutical company 4TEEN4 Pharmaceuticals GmbH (“4TEEN4”). 4TEEN4 has recently licensed DPP3 rights to sphingotec for diagnostic purposes.

“DPP3 represents a unique biomarker at the core of a novel disease mechanism with high potential utility in diagnosing organ dysfunction and predicting outcome in cardiogenic shock as well as in a range of other acute care indications”, said Prof. Mebazaa.

Dr. Andreas Bergmann, CEO and founder of sphingotec commented: “The new disease mechanism investigated by Prof Mebazaa has huge potential to provide novel diagnostic and therapeutic options in a range of acute care settings with high unmet clinical need. To better understand clinical utility of DPP3 in the management of acute care patients, we invite the critical care community to collaborate with us in the further evaluation of this promising biomarker with our fully automated DPP3 point-of-care test in laboratory and near-patient settings.”

Takagi (2019) Circulating dipeptidyl-peptidase 3 and alteration in hemodynamics in cardiogenic shock: Results from the OptimaCC Trial, European Journal of Heart Failure
Deniau (2019) Circulating dipeptidyl peptidase-3 is a myocardial depressant factor: DPP3 inhibition rapidly and sustainably improves hemodynamics, European Journal of Heart Failure
clinicaltrial.gov NCT 01367743
clinicaltrial.gov NCT 1374867

About Acute Heart Failure

Heart failure is a state of reduced cardiac output, in which the heart cannot pump blood through the body effectively. When symptoms appear suddenly, or a person experiences rapid worsening of existing symptoms of heart failure, this is called acute heart failure (AHF) or acute decompensated heart failure (ADHF). This condition can be life threatening and should be urgently evaluated by a physician, as outcomes can be affected by early and appropriate treatment. Heart failure is a common condition affecting more than 30 million people world-wide. Typical symptoms of acute heart failure include shortness of breath, tiredness and swelling of the feet and legs (congestion). Treatment typically involves supporting breathing and adjusting the blood pressure and, where necessary, removing excess fluid from the body by diuretic treatment. There is no cure, but long-term treatment involving medications and rehabilitation can improve the heart’s function.

About Cardiogenic Shock

Cardiogenic shock is an emergency with mortality rates up to 50 %. Most cases of cardiogenic shock occur after myocardial infarction and are defined by persistent low cardiac output state resulting in arterial hypotension, shortness of breath, reduced organ perfusion. Refractory cardiogenic shock presents as persistent organ hypoperfusion despite the administration of vasoactive treatments. Early initiation of mechanical circulatory support, early percutaneous coronary intervention, inotropes, and heart transplantation may improve outcomes for patients with cardiogenic shock.

About DPP3

Human Dipeptidyl Peptidase 3 (DPP3) is an ubiquitously expressed and highly conserved enzyme. DPP3 cleaves various bioactive peptides, such as such as angiotensin II, enkephalins. The most prominent substrate of DPP3 is angiotensin II, the central effector of the renin-angiotensin system (RAS), implicating extracellular DPP3 in the regulation of the RAS. RAS is activated in cardiovascular diseases, sepsis and septic shock and angiotensin II, in particular, has been shown to modulate many cardiovascular functions including the control of blood pressure and cardiac remodelling.

About Nexus Dx Inc. and the IB10 Platform

Nexus Dx Inc., a wholly owned subsidiary of sphingotec,headquartered in San Diego, CA, USA, is a global provider of a near patient testing system and advanced diagnostic solution. The company is improving patient care by providing the medical community with rapid and reliable testing at the point of care (POC), delivering patient information when and where it is needed most. The company has invested over $160m to develop and market the IB10 analyser system which, without the need for sample preparation, automatically separates plasma from whole blood with subsequent reliable and quantitative detection of biomarkers in the plasma by means of antibodies. With a hands-on-time of less than 3 minutes the easy-to-use system provides in only 20 minutes test results for biomarkers that are crucial in the management of critical care patients such as Procalcitonin, Troponin I, CK-MB, Myoglobin, NT-proBNP, and D-Dimer. sphingotecs proprietary test sphingotest(R) DPP3, an assay for Dipeptidyl Peptidase 3, a unique biomarker for signalling pathway disruptions leading to acute organ dysfunction was recently launched on Nexus IB10. Near-term product launches on Nexus IB10 will include: IB10 sphingotest(R) bio-ADM(R), an assay for bioactive Adrenomedullin, a unique biomarker for real-time assessment of vascular integrity, and IB10 sphingotest(R) penKid(R), an assay for Proenkephalin, a unique biomarker for real-time assessment of kidney function.

About sphingotec

SphingoTec GmbH (“sphingotec”; Hennigsdorf by Berlin, Germany) develops and markets innovativein vitro diagnostic IVD tests for novel and proprietarybiomarkers for the diagnosis, prediction and monitoring of acute medical conditions, such as acute heart failure, circulatory shock, and acute kidney injury in order to support patient management and provide guidance for treatment strategies. sphingotec’s assay portfolio includes sphingotest(R) bio-ADM(R) the assay for bioactive adrenomedullin, a unique biomarker for real-time assessment of vascular integrity in conditions like sepsis or congestive heart failure, sphingotest(R) penKid(R), the assay for proenkephalin, a unique biomarker for real-time assessment of kidney function and sphingotest(R) DPP3, an assay for Dipeptidyl Peptidase 3, a unique biomarker for signalling pathway disruptions leading to acute organ dysfunction.Along with the Nexus IB10 POC platform by its subsidiary Nexus Dx Inc. (San Diego, CA, USA) acquired from Samsung in 2018, sphingotec markets a standard marker portfolio for acute care. In addition, sphingotec developed a portfolio of novel biomarkers, which predict the risks of obesity, breast cancer and cardiovascular diseases.

CONTACT:

Deborah Bergmann
Head of Marketing
+ 49 3302 20565 0
d.bergmann@sphingotec.de

Ruxandra Lenz
PR and Market Communications Manager
+ 49 3302 20565 0
lenz@sphingotec.de
www.sphingotec.de

SOURCE: SphingoTec GmbH

ReleaseID: 558111

4TEEN4 Pharmaceuticals Reports First Results on Procizumab, a Novel Therapeutic Anti-DPP3 Antibody for Treatment of Acute Myocardial Depression

PARIS, FRANCE, and HENNIGSDORF/BERLIN, GERMANY / ACCESSWIRE / August 31, 2019 / 4TEEN4 Pharmaceuticals GmbH (“4TEEN4”, former Sphingotec Therapeutics GmbH, Hennigsdorf/Berlin, Germany) today for the first time reported preclinical data on its lead product Procizumab, a therapeutic antibody targeting circulating Dipeptidyl Peptidase 3 (DPP3) for the treatment of patients with acute myocardial depression including acute heart failure and cardiogenic shock. The published data further emphasizes the medical utility of DPP3 as a biomarker predicting organ dysfunction and outcome in critically ill patients.

4TEEN4 Pharmaceuticals GmbH demonstrates that targeting the enzyme Dipeptidyl Peptidase 3 (DPP3) with its first-in-class therapeutic antibodyProcizumab normalises heart and kidney function ina preclinical models of acute heart failure with depressed contraction.

Clinical data presented by Prof. Alexandre Mebazaa at ESC Congress 2019 in Paris provide evidence for a novel disease mechanism in which circulating DPP3degrades central mediators of heart and kidney function, rapidly leading to fatal organ dysfunction.

4TEEN4 Pharmaceuticals GmbH licensed its diagnostic biomarker test DPP3 to SphingoTec GmbH, which today launched the IB10 sphingotest(R) DPP3 assay for use with the Nexus IB10 point-of-care analyser, the first CE-IVD test for DPP3.

DPP3 is at the core of a recently discovered patho-mechanism of acute myocardial depression reported for the first time by Prof. Alexandre Mebazaa (Hôpital Lariboisière, Paris) at ESC Congress 2019 (organised by the European Society of Cardiology ESC, Paris)1. Data from two clinical studies (OptimaCC2and CardShock3) presented by Prof. Mebazaa demonstrate that pathological concentrations of the newly identified myocardial depressant factor DPP3 were clearly associated with organ failure and short-term outcome of patients with cardiogenic shock, an emergency that affects around 10%4of patients with myocardial infarction. Mebazaa’s team hypothesizes that intracellular DPP3 is released from cells into the bloodstream during cell death. They provided striking evidence that DPP3 degrades the cardiovascular mediators angiotensin II and enkephalin, which are central to heart and kidney function.

In pre-clinical models, injections of DPP3 decreased cardiac output, as well as kidney hemodynamics. Administration of Procizumab, a humanized monoclonal antibody designed to block peptidase activity of DPP3, immediately normalized heart and kidney function in a pre-clinical model for acute heart failure. “Procizumab is a novel treatment approach targeting a recently identified DPP3-mediated disease mechanism in critically ill patients”, said Prof. Mebazaa, whose results were also published today in the European Journal of Heart Failure5,6.

4TEEN4 is currently setting up a GMP process for Procizumab manufacturing and is expected to enter regulatory non-clinical safety studies next year.

“In ongoing preclinical efficacy studies, Procizumab has shown high therapeutic potential in certain indications, including heart failure, that are triggered by dysfunction in the cardiorenal axis mediated by low angiotensin II and enkephalin levels. Supported by excellent clinical cohort results on the DPP3 biomarker, we are now preparing for first-in-men clinical trials” said Dr. Andreas Bergmann, CEO of 4TEEN4.

The studies published today and further on-going retrospective studies show promising clinical utility of DPP3 as a biomarker in emergency settings. The company has licensed the global rights to develop DPP3-based diagnostics for near-patient and central laboratory testing to SphingoTec GmbH (“sphingotec”; Hennigsdorf, Germany). 4TEEN4 and sphingotec, together with Nexus Dx Inc. and Adrenomed AG, are part of the Medicine4Future Initiative established by serial entrepreneur Dr. Andreas Bergmann.

References

Circulating dipeptidyl peptidase-3 is a myocardial depressant factor: Procizumab promptly and sustainably restored hemodynamics in heart failure, Prof. Alexandre Mebazaa at ESC Congress 2019, Paris
clinicaltrial.gov NCT 01367743
clinicaltrial.gov NCT 1374867
van Diepen (2017) Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association, Circulation
Takagi (2019) Circulating dipeptidyl-peptidase 3 and alteration in hemodynamics in cardiogenic shock: Results from the OptimaCC Trial, European Journal of Heart Failure
Deniau (2019) Circulating dipeptidyl peptidase-3 is a myocardial depressant factor: DPP3 inhibition rapidly and sustainably improves hemodynamics, European Journal of Heart Failure

About 4TEEN4

4TEEN4 Pharmaceuticals GmbH is a biopharmaceutical company developing Procizumab, a humanized antibody targeting human Dipeptidyl Peptidase 3 (DPP3) for the treatment of acute cardiovascular diseases. 4TEEN4 licenses its proprietary biomarker DPP3 to make it available for diagnostic use in indications as acute heart failure, myocardial infarction, cardiogenic shock, and septic shock. The company was established in 2013 in Hennigsdorf near Berlin, Germany, by Dr. Andreas Bergmann, CEO of 4TEEN4, as part of his Medicine4Future Initiative.

About DPP3

Human Dipeptidyl Peptidase 3 (DPP3) is an ubiquitously expressed and highly conserved enzyme. DPP3 cleaves various bioactive peptides, such as such as angiotensin II, enkephalins. The most prominent substrate of DPP3 is angiotensin II, the central effector of the renin-angiotensin system (RAS), implicating extracellular DPP3 in the regulation of the RAS. The RAS is activated in cardiovascular diseases, sepsis and septic shock and angiotensin II, in particular, has been shown to modulate many cardiovascular functions including the control of blood pressure and cardiac remodelling.

About Procizumab

Procizumab is a humanized monoclonal antibody in pre-clinical development specifically binding circulating Dipeptidyl peptidase 3 (DPP3). It will be a first-in-class drug that targets and modulates DPP3 as an essential regulator of cardiovascular function. Procizumab has an innovative mode of action, relevant in acute diseases. Massive cell death and release of DPP3 into the blood stream lead to degradation of its substrates including angiotensin II and enkephalin, that are responsible for cardio and renal function regulation. Procizumab inhibits the activity of DPP3, thereby reducing bioactive peptide degradation, stabilizing cardiovascular function and potentially increasing survival chances e.g. in acute heart failure. Preclinical studies of Procizumab in models of cardiovascular failure showed instant efficacy. As an example – injection of Procizumab in a model with shock-induced cardiovascular failure (low blood pressure, low shortening fraction) leads to an instant increase of shortening fraction.

About Acute Heart Failure

About Cardiogenic Shock

About Medicine4Future Initiative

The companies of the Medicine4Future Initiative, SphingoTec GmbH, 4TEEN4 Pharmaceuticals GmbH, Adrenomed AG and Nexus Dx Inc., have the common goal to improve the management of critically ill patients and, in future, help preventing the manifestation of common diseases by developing first-in-class diagnostics and targeted therapies in a hypothesis-driven approach that is deeply rooted in a profound understanding of disease biology. Starting from assay development and growing evidence from large cohort studies, blood biomarkers are associated with relevant patient outcomes in underserved medical conditions. Based on data that prove that a biomarker can reliably monitor outcomes, antibodies are subsequently developed to validate if the biomarker also represents a druggable target. If so, drug candidates are tested in appropriate pre-clinical models and consecutively enter first in-men clinical trials. The Medicine4Future Initiative was established by Dr. Andreas Bergmann, one of the founders and former Chief Scientific Officer of B.R.A.H.M.S. AG where he was responsible for the development of the “gold standard” sepsis biomarker Procalcitonin (B.R.A.H.M.S. PCT(TM)).

CONTACT:

Dr. Karine Santos
+49 3302 205650
info@4teen4.de
www.4teen4.de

SOURCE: 4TEEN4 Pharmaceuticals GmbH

ReleaseID: 558110

Selling Training Course Expert E-Commerce Strategies Online Program Launched

Nice Money Publications Limited launched the Six Figure Mentors Training Series, a new online selling course featuring a step-by-step method on how to maximize sales in any industry.

Stafford, United Kingdom – August 31, 2019 /PressCable/ —

Nice Money Publications Limited announced its Six Figure Mentors Training Series, a full step-by-step method teaching practical online selling strategies for business owners, e-commerce entrepreneurs, marketers and anyone else interested in improving their sales success. The course enables participants to develop a value-based selling strategy that provides genuine value to potential customers, rather than simply trying to get them to buy a certain product or service.

More details can be found at http://tidyurl.com/ns8yce

Developing a successful selling strategy is essential for marketers and business owners in any industry. However, when many think about selling, the first things that come to mind are pushy tactics and persuading potential customers at all costs.

Six Figure Mentors Training Series has been specifically developed for entrepreneurs, business owners and aspiring marketers who don’t like traditional sales tactics.

The strategies taught in this online course can be easily applied to sell any type of product or service, and they have been used successfully by business owners and professionals in a variety of industries.

A participant used the strategies to promote his DNA-based fitness and wellbeing business, while a doctor leveraged the SFM principles to expand his medical practice across the US.

Participants who join the program get a complete step-by-step training that requires no previous experience in selling, business management or online entrepreneurship. All it takes is commitment and a willingness to learn and grown.

All purchases are covered by a 30-day no questions asked money-back satisfaction guarantee.

The system has been specifically designed to work for both online and offline selling, making it ideal for all types of businesses.

A spokesperson said: “This simple but effective sales system is not only time-tested it’s also future proof, as it’s all based around how you can get customers to buy in today’s digital world. As long as there are people buying stuff online, this system will work wonders.”

Interested parties can find more information by visiting the above-mentioned website.

Contact Info:
Name: Mark Ford
Email: Send Email
Organization: Nice Money Publications Limited
Address: Newport House Newport Road, Stafford, Staffordshire ST16 1DA, United Kingdom
Website: http://tidyurl.com/ns8yce

Source: PressCable

Release ID: 88913342

Naples FL Digital Marketing Social Media Expert Low Ad Costs Report Launched

A new report has been launched by Social Media Marketing 2020 focusing on how local businesses can save money on their advertising. The agency works with companies to improve their web presence and make more sales.

Naples, United States – August 31, 2019 /NewsNetwork/ —

Social Media Marketing 2020 has launched a new report for small local businesses around Naples, FL looking to save money on advertising. It covers key tips when creating marketing campaigns to help keep costs down and achieve the best results.

More information can be found at: https://socialmediamarketing2020.com

The site explains that Social Media Marketing 2020 is a leading agency with a focus on helping more businesses to achieve success online. The company provides local search optimization solutions, social media services, mobile marketing and more.

Clients looking to grow their business can get in touch for a wide range of marketing services. The team is highly flexible, and can develop solutions to meet the needs of every client.

In its new report, Social Media Marketing 2020 highlights that only 3% to 10% of first time visitors ever buy something from a company website. One way around this is to use retargeting as a marketing tool.

Retargeting and remarketing to prospects who have previously visited the website or clicked on ads is a more affordable way of advertising than the cost of initial traffic.

The report indicates that branding by being everywhere tends to improve credibility because of the associated name recognition. In addition to this, companies are advised to analyze their competition to see their longevity of ads, getting clues to their probable effectiveness.

Attractive images coupled with brief text tends to get more clicks, and it’s worth testing multiple images to see which ones get the best results. Ongoing testing is also advisable.

The company states: “All ad campaigns need to be tracked, then removed or run more frequently depending on results of click through rates and conversions into sales. Headlines should be the highest priority for testing.”

It adds: “Questions rather than statements can generate curiosity and get engagement and clicks. In addition to this, titles should be capitalized for easy reading on electronic devices.”

Other tips include having a list of negative keywords for cost per click campaigns to save on costs, and the 24/7 benefits of chatbots for niche businesses.

Full details of the services offered by Social Media Marketing 2020 can be found on the URL above.

Contact Info:
Name: John Brack
Email: Send Email
Organization: Social Media Marketing 2020
Address: 162 Bristol Lane, Naples, FL 34112, United States
Website: https://socialmediamarketing2020.com/

Source: NewsNetwork

Release ID: 88914051

Bestselling Book by Katie Coates: Real Estate Developers & Community Engagement

“Yes Vote” by Katie Coates is an international bestseller on Amazon in real estate, law, and investment categories. It is for those needing approval from decision makers.

Huntington Beach, United States – August 31, 2019 /PressCable/ —

“Yes Vote” by Katie Coates is an international bestseller on Amazon in real estate, law, and investment categories. It is for those needing approval from decision makers. http://yesvoteplan.com/yes-vote-book/

Katie Coates, an expert in advanced persuasion methods to get decision maker buy-in, has achieved bestselling author status internationally for her book, “Yes Vote: The Public Hearing Plan for Developers.” The book was re-launched earlier this year. It is available on Amazon and through special order at your local bookstore.

It has been named on Amazon as a bestseller in the following categories:

#1 in Real Estate Investments (USA)

#2 in Real Estate (USA)

#1 in Land Use Law (USA)

#1 in Administrative Law (USA)

#1 in Law (USA)

#2 in Administrative Law (UK)

#2 in Nonfiction Law (Japan)

#2 in Professional & Technical Law (Japan)

#2 in Reference Law (Japan)

#1 in Land Use Law (Canada)

#4 in Investing (Canada)

#1 in Land Use Law (AUS)

#1 in Real Estate Investments (AUS)

#2 in Law in English (Brazil)

#2 in Law in Foreign Languages (Brazil)

More information on the book can be found here: http://yesvoteplan.com/yes-vote-book/

This is the eleventh book Coates has authored. The book was written with the aim to provide help to those needing to influence decision makers. There’s also particular excitement about this launch because it will unveil all of the author’s best secrets.

Yes Vote: The Public Hearing Plan for Developers sets its main focus on case studies and lessons learned from 20 years in overcoming real estate project opponents. Readers will likely find a particular interest in particular details about packaging information to set the stage for approval.

“The brain needs information that is simplified, repetitive, emotion-based, and – above all – visual,” says Katie Coates.

Yes Vote: The Public Hearing Plan for Developers is published by Morgan James.

Katie Coates has a background as an award-winning consultant with expertise in overcoming opposition, building community support, and getting approval for her clients’ projects.. Katie learned the ropes of overcoming opposition by going door-to-door to inform the public about controversial construction projects.

Another part of her background was unexpectedly helpful to her in getting clients the approvals they need. She studied acting at the University of North Carolina School of the Arts, and acted, sang and danced in 40 productions throughout high school and college.

“The public hearing is very similar to the theater,” says Katie Coates. “You need to put on a show.”

She also credits her experience as a waitress with giving her expertise in crisis communications because, as she puts it, “Hungry people are very mean.”

When asked why she wrote the book, Katie Coates said, “I kept seeing real estate developers get defeated at public hearings and knew they could prevail instead, with the right information. There was no other book on the market on this topic, so I decided to write it.”

Katie Coates has hopes that the book will help project applicants take control of their experience at public hearings and get decision maker approval. The book’s creation was a bit of a challenge. At one point during the writing process, the author had three extended trips scheduled.

“I wrote one long chapter while on a flight to Copenhagen, using Google Keep as a transcriber,” says Katie Coates. “I spoke low enough so that I didn’t wake my seat mate, who was luckily wearing earbuds while she slept.”

In a recent interview, the author made a point of thanking her friends, family, and clients, who all encouraged her to write this book, saying, “My dad, a retired Green Beret and 82nd Airborne Paratrooper, has always been very supportive of me. He suggested that I become a consultant right after I graduated from college. It took me a few years to get there, but I finally did. It’s been great to have his confidence in me as an encouraging force throughout my career.”

Those interested in getting a free copy of the book emailed to them in pdf format can visit this site: http://yesvoteplan.com/yes-vote-book/

About the Author

Katie Coates has been a public relations practitioner for 30 years and has had her own consulting practice for 21 years. She has a lot of letters and other stuff after her name. She also went to college and did post-graduate work. Those things are boring, so we’ll skip them.

Her book “Yes Vote: The Public Hearing Plan for Developers.” was published this year. It has been called “an invaluable resource for developers” and the key that will help readers “influence decision makers of any kind.”

Katie produces the Yes Vote Marketing Podcast and her tips for obtaining decision maker buy-in have been featured by many national media outlets.

Katie lectures at several Southern California universities on the topic of crisis communications. She will be a featured speaker at the Public Relations Society of America International Conference in San Diego in October.

Contact Info:
Name: Katie Coates
Email: Send Email
Organization: PRP Press
Address: 9121 Atlanta Avenue #101, Huntington Beach, CA 92646, United States
Phone: +1-877-881-2027;ext=102

Source: PressCable

Release ID: 88914082